Next Article in Journal
Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages
Next Article in Special Issue
Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids
Previous Article in Journal
Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides
Previous Article in Special Issue
The Role of microRNA in Head and Neck Cancer: Current Knowledge and Perspectives
Article Menu

Export Article

Open AccessReview
Molecules 2014, 19(5), 5821-5862; doi:10.3390/molecules19055821

Significance and Therapeutic Value of miRNAs in Embryonal Neural Tumors

Department of Oncology, University Children's Hospital of Zurich, Zurich 8008, Switzerland
Author to whom correspondence should be addressed.
Received: 3 March 2014 / Revised: 25 April 2014 / Accepted: 28 April 2014 / Published: 6 May 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
View Full-Text   |   Download PDF [334 KB, uploaded 18 June 2014]


Embryonal tumors of the nervous system are the leading cause of childhood cancer-related morbidity and mortality. Medulloblastoma, supratentorial primitive neuroectodermal tumors, atypical teratoid/rhabdoid tumor and neuroblastoma account for more than 20% of childhood malignancies and typify the current neural embryonal tumor model in pediatric oncology. Mechanisms driving the formation of these tumors point towards impaired differentiation of neuronal and neuron-associated cells during the development of the nervous system as an important factor. The importance of microRNAs (miRNAs) for proper embryonic cell function has been confirmed and their aberrant expressions have been linked to tumor development. The role of miRNAs in controlling essential regulators of key pathways implicated in tumor development makes their use in diagnostics a powerful tool to be used for early detection of cancer, risk assessment and prognosis, as well as for the design of innovative therapeutic strategies. In this review we focus on the significance of miRNAs involved in the biology of embryonal neural tumors, delineate their clinical significance and discuss their potential as a novel therapeutic target. View Full-Text
Keywords: embryonal tumors; microRNAs; medulloblastoma; sPNET; AT/RT; neuroblastoma embryonal tumors; microRNAs; medulloblastoma; sPNET; AT/RT; neuroblastoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shalaby, T.; Fiaschetti, G.; Baumgartner, M.; Grotzer, M.A. Significance and Therapeutic Value of miRNAs in Embryonal Neural Tumors. Molecules 2014, 19, 5821-5862.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top