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Molecules 2014, 19(5), 5599-5610; doi:10.3390/molecules19055599
Article

Non-Conventional Methodologies in the Synthesis of 1-Indanones

1
, 2
, 1
, 1
, 3
, 4
 and 1,*
1 Dipartimento di Scienze della Salute, Università Magna Graecia, Viale Europa, Germaneto (CZ) 88100, Italy 2 Dipartimento di Chimica, Università della Calabria, Cubo 12C, Arcavacata di Rende (CS) 87036, Italy 3 Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Pietro Giuria 9, Torino 10125, Italy 4 Dipartimento Scienza del Farmaco e Prodotti per la salute, Università di Messina, Via Santissima Annunziata, Messina 98168, Italy,
* Author to whom correspondence should be addressed.
Received: 2 April 2014 / Revised: 19 April 2014 / Accepted: 23 April 2014 / Published: 30 April 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube™ reactor. A library of differently substituted 1-indanones has been prepared via one-pot intramolecular Friedel-Crafts acylation and their efficiency and “greenness” have been compared.
Keywords: 1-indanones; microwaves; ultrasound; Q-tube™; Friedel-Crafts acylation 1-indanones; microwaves; ultrasound; Q-tube™; Friedel-Crafts acylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oliverio, M.; Nardi, M.; Costanzo, P.; Cariati, L.; Cravotto, G.; Giofrè, S.V.; Procopio, A. Non-Conventional Methodologies in the Synthesis of 1-Indanones. Molecules 2014, 19, 5599-5610.

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