Next Article in Journal
Anti-Amoebic Properties of Carbonyl Thiourea Derivatives
Previous Article in Journal
Development of Simple Sequence Repeat (SSR) Markers of Sesame (Sesamum indicum) from a Genome Survey
Molecules 2014, 19(4), 5163-5190; doi:10.3390/molecules19045163
Article

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

1,* , 1
,
1
,
1
 and
2
1 Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt 2 Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
* Author to whom correspondence should be addressed.
Received: 6 March 2014 / Revised: 9 April 2014 / Accepted: 14 April 2014 / Published: 22 April 2014
View Full-Text   |   Download PDF [584 KB, uploaded 18 June 2014]   |  

Abstract

The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole  and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.
Keywords: oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

El Sadek, M.M.; Abd El-Dayem, N.S.; Hassan, S.Y.; Mostafa, M.A.; Yacout, G.A. Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives. Molecules 2014, 19, 5163-5190.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert