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Molecules 2014, 19(4), 5163-5190; doi:10.3390/molecules19045163
Article

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

1,* , 1
, 1
, 1
 and 2
Received: 6 March 2014; in revised form: 9 April 2014 / Accepted: 14 April 2014 / Published: 22 April 2014
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Abstract: The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole  and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.
Keywords: oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

El Sadek, M.M.; Abd El-Dayem, N.S.; Hassan, S.Y.; Mostafa, M.A.; Yacout, G.A. Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives. Molecules 2014, 19, 5163-5190.

AMA Style

El Sadek MM, Abd El-Dayem NS, Hassan SY, Mostafa MA, Yacout GA. Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives. Molecules. 2014; 19(4):5163-5190.

Chicago/Turabian Style

El Sadek, Mohamed M.; Abd El-Dayem, Nagwa S.; Hassan, Seham Y.; Mostafa, Mohamed A.; Yacout, Galila A. 2014. "Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives." Molecules 19, no. 4: 5163-5190.



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