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Molecules 2014, 19(4), 5163-5190; doi:10.3390/molecules19045163

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

1
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
2
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
*
Author to whom correspondence should be addressed.
Received: 6 March 2014 / Revised: 9 April 2014 / Accepted: 14 April 2014 / Published: 22 April 2014
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Abstract

The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole  and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity. View Full-Text
Keywords: oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant oxoindoline; isopropylidene; pyrrole; indole; isoindole; oxadiazole; pyrazole; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

El Sadek, M.M.; Abd El-Dayem, N.S.; Hassan, S.Y.; Mostafa, M.A.; Yacout, G.A. Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives. Molecules 2014, 19, 5163-5190.

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