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Molecules 2014, 19(4), 4802-4813; doi:10.3390/molecules19044802
Article

Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds

, , , ,  and *
Received: 7 February 2014; in revised form: 27 March 2014 / Accepted: 8 April 2014 / Published: 16 April 2014
(This article belongs to the Section Metabolites)
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Abstract: Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.
Keywords: Cucurbita maxima; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity Cucurbita maxima; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kikuchi, T.; Ueda, S.; Kanazawa, J.; Naoe, H.; Yamada, T.; Tanaka, R. Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds. Molecules 2014, 19, 4802-4813.

AMA Style

Kikuchi T, Ueda S, Kanazawa J, Naoe H, Yamada T, Tanaka R. Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds. Molecules. 2014; 19(4):4802-4813.

Chicago/Turabian Style

Kikuchi, Takashi; Ueda, Shinsuke; Kanazawa, Jokaku; Naoe, Hiroki; Yamada, Takeshi; Tanaka, Reiko. 2014. "Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds." Molecules 19, no. 4: 4802-4813.


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