Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
AbstractThree new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.
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Kikuchi, T.; Ueda, S.; Kanazawa, J.; Naoe, H.; Yamada, T.; Tanaka, R. Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds. Molecules 2014, 19, 4802-4813.
Kikuchi T, Ueda S, Kanazawa J, Naoe H, Yamada T, Tanaka R. Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds. Molecules. 2014; 19(4):4802-4813.Chicago/Turabian Style
Kikuchi, Takashi; Ueda, Shinsuke; Kanazawa, Jokaku; Naoe, Hiroki; Yamada, Takeshi; Tanaka, Reiko. 2014. "Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds." Molecules 19, no. 4: 4802-4813.