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Molecules 2014, 19(4), 4802-4813; doi:10.3390/molecules19044802
Article

Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds

, , , ,  and *
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan
* Author to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 27 March 2014 / Accepted: 8 April 2014 / Published: 16 April 2014
(This article belongs to the Section Natural Products)
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Abstract

Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.
Keywords: Cucurbita maxima; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity Cucurbita maxima; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kikuchi, T.; Ueda, S.; Kanazawa, J.; Naoe, H.; Yamada, T.; Tanaka, R. Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds. Molecules 2014, 19, 4802-4813.

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