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Molecules 2014, 19(4), 4770-4778; doi:10.3390/molecules19044770

Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic
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Received: 28 January 2014 / Revised: 17 March 2014 / Accepted: 11 April 2014 / Published: 16 April 2014
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Abstract

This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
Keywords: granulocyte colony-stimulating factor; radiation accidents; acute radiation syndrome; radiation-induced myelosuppression granulocyte colony-stimulating factor; radiation accidents; acute radiation syndrome; radiation-induced myelosuppression
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hofer, M.; Pospíšil, M.; Komůrková, D.; Hoferová, Z. Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review. Molecules 2014, 19, 4770-4778.

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