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Molecules 2014, 19(4), 4284-4300; doi:10.3390/molecules19044284

Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

1
Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, Cali 760032, Colombia
2
Department of Inorganic and Organic Chemistry, Universidad de Jaén, Jaén 23071, Spain
*
Author to whom correspondence should be addressed.
Received: 6 February 2014 / Revised: 27 March 2014 / Accepted: 28 March 2014 / Published: 4 April 2014
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [474 KB, 18 June 2014; original version 18 June 2014]   |  

Abstract

Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylides formed in situ via a 1,3-dipolar cycloaddition reaction. View Full-Text
Keywords: dipyrrolo [3,4-a:3',4'-f]pyrrolizines; pyrrolo[3,4-c]pirroles; 1,3-dipolar cycloadditions; multicomponent reactions; domino reactions dipyrrolo [3,4-a:3',4'-f]pyrrolizines; pyrrolo[3,4-c]pirroles; 1,3-dipolar cycloadditions; multicomponent reactions; domino reactions
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Quiroga, J.; Gálvez, J.; Abonia, R.; Insuasty, B.; Ortíz, A.; Cobo, J.; Nogueras, M. Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process. Molecules 2014, 19, 4284-4300.

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