Molecules 2014, 19(4), 4189-4199; doi:10.3390/molecules19044189
Article

Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa

1, 1, 1, 1 and 2,* email
Received: 18 February 2014; in revised form: 24 March 2014 / Accepted: 28 March 2014 / Published: 3 April 2014
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The edible mushroom Agaricus blazei Murill is known to induce protective immunomodulatory action against a variety of infectious diseases. In the present study we report potential anti-quorum sensing properties of A. blazei hot water extract. Quorum sensing (QS) plays an important role in virulence, biofilm formation and survival of many pathogenic bacteria, including the Gram negative Pseudomonas aeruginosa, and is considered as a novel and promising target for anti-infectious agents. In this study, the effect of the sub-MICs of Agaricus blazei water extract on QS regulated virulence factors and biofilm formation was evaluated against P. aeruginosa PAO1. Sub-MIC concentrations of the extract which did not kill P. aeruginosa nor inhibited its growth, demonstrated a statistically significant reduction of virulence factors of P. aeruginosa, such as pyocyanin production, twitching and swimming motility. The biofilm forming capability of P. aeruginosa was also reduced in a concentration-dependent manner at sub-MIC values. Water extract of A. blazei is a promising source of antiquorum sensing and antibacterial compounds.
Keywords: Agaricus blazei; mushroom; antiqourum sensing activity; antimicrobial activity; antibiofilm activity; Pseudomonas aeruginosa
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MDPI and ACS Style

Soković, M.; Ćirić, A.; Glamočlija, J.; Nikolić, M.; van Griensven, L.J.L.D. Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa. Molecules 2014, 19, 4189-4199.

AMA Style

Soković M, Ćirić A, Glamočlija J, Nikolić M, van Griensven LJLD. Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa. Molecules. 2014; 19(4):4189-4199.

Chicago/Turabian Style

Soković, Marina; Ćirić, Ana; Glamočlija, Jasmina; Nikolić, Miloš; van Griensven, Leo J.L.D. 2014. "Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa." Molecules 19, no. 4: 4189-4199.

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