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Molecules 2014, 19(4), 4076-4082; doi:10.3390/molecules19044076
Communication

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

1,†,* , 2,†, 2, 1, 1 and 2
1 Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria 2 Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 21 March 2014 / Accepted: 24 March 2014 / Published: 2 April 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 28 in a single step.
Keywords: chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shanab, K.; Neudorfer, C.; Holzer, W.; Mitterhauser, M.; Wadsak, W.; Spreitzer, H. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules 2014, 19, 4076-4082.

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