Molecules 2014, 19(4), 4076-4082; doi:10.3390/molecules19044076
Communication

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

1,†,* email, 2,†, 2, 1, 1 and 2
Received: 28 January 2014; in revised form: 21 March 2014 / Accepted: 24 March 2014 / Published: 2 April 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 28 in a single step.
Keywords: chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer
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MDPI and ACS Style

Shanab, K.; Neudorfer, C.; Holzer, W.; Mitterhauser, M.; Wadsak, W.; Spreitzer, H. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules 2014, 19, 4076-4082.

AMA Style

Shanab K, Neudorfer C, Holzer W, Mitterhauser M, Wadsak W, Spreitzer H. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules. 2014; 19(4):4076-4082.

Chicago/Turabian Style

Shanab, Karem; Neudorfer, Catharina; Holzer, Wolfgang; Mitterhauser, Markus; Wadsak, Wolfgang; Spreitzer, Helmut. 2014. "A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer." Molecules 19, no. 4: 4076-4082.

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