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Molecules 2014, 19(4), 4076-4082; doi:10.3390/molecules19044076
Communication

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

1,†,* , 2,†, 2, 1, 1 and 2
1 Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria 2 Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 21 March 2014 / Accepted: 24 March 2014 / Published: 2 April 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 28 in a single step.
Keywords: chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shanab, K.; Neudorfer, C.; Holzer, W.; Mitterhauser, M.; Wadsak, W.; Spreitzer, H. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules 2014, 19, 4076-4082.

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