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Molecules 2014, 19(2), 2536-2545; doi:10.3390/molecules19022536

Skullcap (Scutellaria baicalensis) Extract and Its Active Compound, Wogonin, Inhibit Ovalbumin-Induced Th2-Mediated Response

Division of Metabolism & Functionality Research, Korea Food Research Institute, 1201-62, Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Korea
Institute for Basic Science, School of Biological Sciences, Seoul National University, 599, Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
Author to whom correspondence should be addressed.
Received: 3 January 2014 / Revised: 10 February 2014 / Accepted: 18 February 2014 / Published: 21 February 2014
(This article belongs to the Section Natural Products)
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Skullcap (Scutellaria baicalensis) has been widely used as a dietary ingredient and traditional herbal medicine owing to its anti-inflammatory and anticancer properties. In this study, we investigated the anti-allergic effects of skullcap and its active compounds, focusing on T cell-mediated responses ex vivo and in vivo. Splenocytes from mice sensitized with ovalbumin (OVA) were isolated for analyses of cytokine production and cell viability. Mice sensitized with OVA were orally administered skullcap or wogonin for 16 days, and then immunoglobulin (Ig) and cytokine levels were measured by enzyme-linked immunosorbent assays. Treatment with skullcap significantly inhibited interleukin (IL)-4 production without reduction of cell viability. Moreover, wogonin, but not baicalin and baicalein, suppressed IL-4 and interferon-gamma production. In vivo, skullcap and wogonin downregulated OVA-induced Th2 immune responses, especially IgE and IL-5 prediction. Wogonin as an active component of skullcap may be applied as a therapeutic agent for IgE- and IL-5-mediated allergic disorders.
Keywords: skullcap; wogonin; anti-allergy; IgE; IL-5; Th2 response skullcap; wogonin; anti-allergy; IgE; IL-5; Th2 response

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shin, H.S.; Bae, M.-J.; Choi, D.W.; Shon, D.-H. Skullcap (Scutellaria baicalensis) Extract and Its Active Compound, Wogonin, Inhibit Ovalbumin-Induced Th2-Mediated Response. Molecules 2014, 19, 2536-2545.

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