Molecules 2014, 19(2), 2213-2225; doi:10.3390/molecules19022213
Article

Synthesis of ∆3-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells

Received: 17 January 2014; in revised form: 9 February 2014 / Accepted: 11 February 2014 / Published: 20 February 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of ∆3-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail on the natural product could be subtly modified to enhance the activity and the aromatic moiety or the terminal olefin on the main chain can also be modified without any evident loss of activity. The stereo-configuration of the quaternary chiral center has an important influence on the activity.
Keywords: bakuchiol; natural product analogues; cytotoxic activity
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MDPI and ACS Style

Zhao, Q.; Xu, Q.; Shan, G.; Dong, C.; Zhang, H.; Lei, X. Synthesis of ∆3-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells. Molecules 2014, 19, 2213-2225.

AMA Style

Zhao Q, Xu Q, Shan G, Dong C, Zhang H, Lei X. Synthesis of ∆3-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells. Molecules. 2014; 19(2):2213-2225.

Chicago/Turabian Style

Zhao, Qun; Xu, Qianqian; Shan, Guangsheng; Dong, Chao; Zhang, Hong; Lei, Xinsheng. 2014. "Synthesis of ∆3-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells." Molecules 19, no. 2: 2213-2225.

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