Molecules 2014, 19(2), 2049-2060; doi:10.3390/molecules19022049

Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

1,2,†email, 3,†email, 4,5email, 6email, 3email, 3email, 7email, 3email, 8email, 1,9,10,11email, 1,12,13,* email and 12,* email
Received: 10 January 2014; in revised form: 30 January 2014 / Accepted: 3 February 2014 / Published: 13 February 2014
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)- methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (48). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13-dien-15-oic acid (7) showed promising NO inhibitory activity at 10 µg/mL, with 81.1% and 86.3%, inhibition, respectively.
Keywords: clerodane diterpenes; Polyalthia longifolia var. pendula; Annonaceae; anti-inflammatory
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MDPI and ACS Style

Wu, T.-H.; Cheng, Y.-Y.; Chen, C.-J.; Ng, L.-T.; Chou, L.-C.; Huang, L.-J.; Chen, Y.-H.; Kuo, S.-C.; El-Shazly, M.; Wu, Y.-C.; Chang, F.-R.; Liaw, C.-C. Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula. Molecules 2014, 19, 2049-2060.

AMA Style

Wu T-H, Cheng Y-Y, Chen C-J, Ng L-T, Chou L-C, Huang L-J, Chen Y-H, Kuo S-C, El-Shazly M, Wu Y-C, Chang F-R, Liaw C-C. Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula. Molecules. 2014; 19(2):2049-2060.

Chicago/Turabian Style

Wu, Tung-Ho; Cheng, Yung-Yi; Chen, Chao-Jung; Ng, Lean-Teik; Chou, Li-Chen; Huang, Li-Jiau; Chen, Yung-Husan; Kuo, Sheng-Chu; El-Shazly, Mohamed; Wu, Yang-Chang; Chang, Fang-Rong; Liaw, Chih-Chuang. 2014. "Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula." Molecules 19, no. 2: 2049-2060.

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