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Molecules 2014, 19(2), 2049-2060; doi:10.3390/molecules19022049
Article

Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

1,2,†
, 3,†
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Received: 10 January 2014 / Revised: 30 January 2014 / Accepted: 3 February 2014 / Published: 13 February 2014
(This article belongs to the Section Metabolites)
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Abstract

Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)- methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (48). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13-dien-15-oic acid (7) showed promising NO inhibitory activity at 10 µg/mL, with 81.1% and 86.3%, inhibition, respectively.
Keywords: clerodane diterpenes; Polyalthia longifolia var. pendula; Annonaceae; anti-inflammatory clerodane diterpenes; Polyalthia longifolia var. pendula; Annonaceae; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wu, T.-H.; Cheng, Y.-Y.; Chen, C.-J.; Ng, L.-T.; Chou, L.-C.; Huang, L.-J.; Chen, Y.-H.; Kuo, S.-C.; El-Shazly, M.; Wu, Y.-C.; Chang, F.-R.; Liaw, C.-C. Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula. Molecules 2014, 19, 2049-2060.

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