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Open AccessCommunication
Molecules 2014, 19(12), 20340-20349; doi:10.3390/molecules191220340

Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion

1
Enviromental Agriculture Research Division, Gyeonggido Agricultural Reaearch and Extension Services(GARES), Hwaseong, Gyeonggi-do 445-784, Korea
2
Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea
3
LINC project group, University Industry Cooperation, Daejeon University, Daejeon 300-716, Korea
4
Department of Plant Resources, Kongju National University, Yesan 340-702, Korea
5
Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea
6
Department of Chemistry, Mokwon University, Daejeon 302-729, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 6 November 2014 / Revised: 2 December 2014 / Accepted: 2 December 2014 / Published: 4 December 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation. View Full-Text
Keywords: Bupleurum falcatum L.; triterpenoid saponin; saikosaponin; selectin; cell adhesion molecules; anti-inflammatory agents Bupleurum falcatum L.; triterpenoid saponin; saikosaponin; selectin; cell adhesion molecules; anti-inflammatory agents
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jang, M.-J.; Kim, Y.S.; Bae, E.Y.; Oh, T.-S.; Choi, H.-J.; Lee, J.-H.; Oh, H.-M.; Lee, S.W. Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion. Molecules 2014, 19, 20340-20349.

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