Anticancer Agents Targeted to Sirtuins
AbstractSirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment. View Full-Text
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Kozako, T.; Suzuki, T.; Yoshimitsu, M.; Arima, N.; Honda, S.-I.; Soeda, S. Anticancer Agents Targeted to Sirtuins. Molecules 2014, 19, 20295-20313.
Kozako T, Suzuki T, Yoshimitsu M, Arima N, Honda S-I, Soeda S. Anticancer Agents Targeted to Sirtuins. Molecules. 2014; 19(12):20295-20313.Chicago/Turabian Style
Kozako, Tomohiro; Suzuki, Takayoshi; Yoshimitsu, Makoto; Arima, Naomichi; Honda, Shin-ichiro; Soeda, Shinji. 2014. "Anticancer Agents Targeted to Sirtuins." Molecules 19, no. 12: 20295-20313.