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Molecules 2014, 19(12), 19868-19879; doi:10.3390/molecules191219868

New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus

1
Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China
2
School of Chemistry and Chemical Engineering, Xi'an University, Xi'an 710065, China
3
Department of Physics, School of Science, Tianjin University, Tianjin 300072, China
4
Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 24 July 2014 / Revised: 23 October 2014 / Accepted: 29 October 2014 / Published: 28 November 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Five novel biscoumarins 15 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O–H···O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC) by the means of minimum inhibitory concentration and time-kill curves. View Full-Text
Keywords: biscoumarin; Staphylococcus aureus; minimum inhibitory concentration biscoumarin; Staphylococcus aureus; minimum inhibitory concentration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Qu, D.; Li, J.; Yang, X.-H.; Zhang, Z.-D.; Luo, X.-X.; Li, M.-K.; Li, X. New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus. Molecules 2014, 19, 19868-19879.

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