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Correction published on 9 February 2015, see Molecules 2015, 20(2), 2835-2836.

Open AccessArticle
Molecules 2014, 19(12), 19648-19664; doi:10.3390/molecules191219648

Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment

1
Chemistry Department, Faculty of Science, Aswan University, Aswan 81528, Egypt
2
Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia
3
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
4
Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt
*
Author to whom correspondence should be addressed.
Received: 29 September 2014 / Revised: 17 November 2014 / Accepted: 18 November 2014 / Published: 26 November 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

6-Hydroxy-2-oxo-2H-chromene-4-carbaldehyde (2), 6-chloro-2-oxo-2H-chromene-4-carbaldehyde (3) and 6-hydrazinyl-4-methyl-2H-chromen-2-one (5) were prepared as single-pharmacophore motif key intermediates. Compounds 2, 3 and 5 were incorporated in a series of multicomponent reactions (MCRs), under microwave assistance as well as conventional chemical synthesis processes, to afford a series of three and/or four-pharmacophoric-motif conjugates 8a,b, 11, 13, 16, 17, 19 and 20 in good yields. The newly synthesized compounds were characterized by IR, NMR, 13C-NMR, MS and elemental analyses. Finally the synthesized compounds have been screened for their biological activity whereupon they exhibited remarkable antimicrobial activity on different classes of bacteria and the fungus. View Full-Text
Keywords: multicomponent reactions (MCRs); green synthesis; microwave irradiation; 2-H-chromene; thiazolidenone; biological activity multicomponent reactions (MCRs); green synthesis; microwave irradiation; 2-H-chromene; thiazolidenone; biological activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

El Azab, I.H.; Youssef, M.M.; Amin, M.A. Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment. Molecules 2014, 19, 19648-19664.

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