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Molecules 2014, 19(11), 17848-17861; doi:10.3390/molecules191117848

Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique

1
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, Brno 61242, Czech Republic
2
Nanotechnology Centre, VSB—Technical University of Ostrava, 17. listopadu 15/2172, Ostrava 70833, Czech Republic
3
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, Bratislava 83232, Slovakia
*
Author to whom correspondence should be addressed.
Received: 29 August 2014 / Revised: 23 October 2014 / Accepted: 24 October 2014 / Published: 4 November 2014
(This article belongs to the Section Molecular Diversity)
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Abstract

One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle size of sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10.5 nm. View Full-Text
Keywords: risedronate sodium; nanoparticles; excipients; solvent evaporation; dynamic light scattering; infrared spectroscopy; scanning electron microscopy risedronate sodium; nanoparticles; excipients; solvent evaporation; dynamic light scattering; infrared spectroscopy; scanning electron microscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vaculikova, E.; Placha, D.; Pisarcik, M.; Peikertova, P.; Dedkova, K.; Devinsky, F.; Jampilek, J. Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique. Molecules 2014, 19, 17848-17861.

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