Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide
AbstractHydrochlorothiazide is a diuretic used to treat hypertension that belongs to class IV of the Biopharmaceutics Classification System. The drug was evaluated by quality control, thermal characterization tests, and pharmaceutical formulation compatibility studies. It was concluded that the generic drug, Lab 2, was not a pharmaceutical equivalent. The compounded drugs, Lab 5 and Lab 6, produced unsatisfactory but expected results, since there is no requirement for dissolution and dissolution profile testing for the commercialization of these products. In a compatibility study, lactose and mannitol were shown to be incompatible with HCTZ, which may explain the lack of equivalence of the generic pharmaceutical product, associated with other situations. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
de Oliveira, M.A.; Yoshida, M.I.; Silva, D.C.G.M. Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide. Molecules 2014, 19, 16824-16836.
de Oliveira MA, Yoshida MI, Silva DCGM. Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide. Molecules. 2014; 19(10):16824-16836.Chicago/Turabian Style
de Oliveira, Marcelo A.; Yoshida, Maria I.; Silva, Daphne C.G.M. 2014. "Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide." Molecules 19, no. 10: 16824-16836.