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Molecules 2014, 19(10), 16684-16692; doi:10.3390/molecules191016684

Production of Anti-Cancer Agent Using Microbial Biotransformation

1
Division of Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea
2
Ministry of Environment, Daegu Regional Environmental Office, Government Complex, Hwaam-ro, Dalseo-Gu, Daegu 704-841, Korea
*
Authors to whom correspondence should be addressed.
Received: 4 September 2014 / Revised: 10 October 2014 / Accepted: 11 October 2014 / Published: 16 October 2014
(This article belongs to the Section Molecular Diversity)
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Abstract

Microbial biotransformation is a great model system to produce drugs and biologically active compounds. In this study, we elucidated the fermentation and production of an anti-cancer agent from a microbial process for regiospecific hydroxylation of resveratrol. Among the strains examined, a potent strain showed high regiospecific hydroxylation activity to produce piceatannol. In a 5 L (w/v 3 L) jar fermentation, this wild type Streptomyces sp. in the batch system produced 205 mg of piceatannol (i.e., 60% yields) from 342 mg of resveratrol in 20 h. Using the product, an in vitro anti-cancer study was performed against a human cancer cell line (HeLa). It showed that the biotransformed piceatannol possessed a significant anticancer activity. This result demonstrates that a biotransformation screening method might be of therapeutic interest with respect to the identification of anti-cancer drugs. View Full-Text
Keywords: biotransformation; screening; production; fermentation biotransformation; screening; production; fermentation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roh, C.; Kang, C. Production of Anti-Cancer Agent Using Microbial Biotransformation. Molecules 2014, 19, 16684-16692.

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