Molecules 2014, 19(1), 641-650; doi:10.3390/molecules19010641
Article

Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model

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Received: 31 October 2013; in revised form: 4 December 2013 / Accepted: 17 December 2013 / Published: 7 January 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1ad were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.
Keywords: chalcone; embryogenesis; muscle; toxicity; zebrafish
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MDPI and ACS Style

Lee, Y.-T.; Fong, T.-H.; Chen, H.-M.; Chang, C.-Y.; Wang, Y.-H.; Chern, C.-Y.; Chen, Y.-H. Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model. Molecules 2014, 19, 641-650.

AMA Style

Lee Y-T, Fong T-H, Chen H-M, Chang C-Y, Wang Y-H, Chern C-Y, Chen Y-H. Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model. Molecules. 2014; 19(1):641-650.

Chicago/Turabian Style

Lee, Ya-Ting; Fong, Tsorng-Harn; Chen, Hui-Min; Chang, Chao-Yuan; Wang, Yun-Hsin; Chern, Ching-Yuh; Chen, Yau-Hung. 2014. "Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model." Molecules 19, no. 1: 641-650.


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