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Molecules 2014, 19(1), 568-580; doi:10.3390/molecules19010568
Article

Hormesis of Glyceollin I, an Induced Phytoalexin from Soybean, on Budding Yeast Chronological Lifespan Extension

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Received: 25 November 2013 / Revised: 19 December 2013 / Accepted: 20 December 2013 / Published: 6 January 2014
(This article belongs to the Section Metabolites)
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Abstract

Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (μM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.
Keywords: chronological life span; glyceollin I; hormesis; induced phytoalexin; aging chronological life span; glyceollin I; hormesis; induced phytoalexin; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, Y.; Wu, Z.; Feng, S.; Yang, X.; Huang, D. Hormesis of Glyceollin I, an Induced Phytoalexin from Soybean, on Budding Yeast Chronological Lifespan Extension. Molecules 2014, 19, 568-580.

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