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Molecules 2014, 19(1), 263-278; doi:10.3390/molecules19010263
Article

The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity

1,†,* , 2,†
, 1
, 3
, 1
, 1
 and 4,*
1 Guangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, China 2 College of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China 3 Shenzhen Xinpeng Shengwu Gongcheng Co. LTD, Shenzhen 518055, Guangdong, China 4 School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 13 November 2013 / Revised: 10 December 2013 / Accepted: 13 December 2013 / Published: 27 December 2013
(This article belongs to the Section Metabolites)
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Abstract

This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), together with six known phenolics 38, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 13, 78 were tested, the phenolics 13, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125–50 µg/mL. In addition, the phenolics 13 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 µg/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health.
Keywords: phenolic; flavane; Livistona chinensis; osteoporosis; oxidative stress phenolic; flavane; Livistona chinensis; osteoporosis; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zeng, X.; Tian, J.; Cui, L.; Wang, Y.; Su, Y.; Zhou, X.; He, X. The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity. Molecules 2014, 19, 263-278.

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