Molecules 2014, 19(1), 263-278; doi:10.3390/molecules19010263
Article

The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity

1,†,* email, 2,†email, 1email, 3email, 1email, 1email and 4,* email
Received: 13 November 2013; in revised form: 10 December 2013 / Accepted: 13 December 2013 / Published: 27 December 2013
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), together with six known phenolics 38, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 13, 78 were tested, the phenolics 13, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125–50 µg/mL. In addition, the phenolics 13 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 µg/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health.
Keywords: phenolic; flavane; Livistona chinensis; osteoporosis; oxidative stress
PDF Full-text Download PDF Full-Text [1053 KB, uploaded 18 June 2014 20:18 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zeng, X.; Tian, J.; Cui, L.; Wang, Y.; Su, Y.; Zhou, X.; He, X. The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity. Molecules 2014, 19, 263-278.

AMA Style

Zeng X, Tian J, Cui L, Wang Y, Su Y, Zhou X, He X. The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity. Molecules. 2014; 19(1):263-278.

Chicago/Turabian Style

Zeng, Xiaobin; Tian, Jun; Cui, Liao; Wang, Yang; Su, Yanjie; Zhou, Xin; He, Xiangjiu. 2014. "The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity." Molecules 19, no. 1: 263-278.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert