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Molecules 2014, 19(1), 1344-1352; doi:10.3390/molecules19011344

Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

1,*  and 1,*
1 School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Wuhan Biocause Pharmaceutical Development Co., Ltd, Wuhan 430056, Hubei, China 3 College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, Hubei, China 4 Hubei Biocause Heilen Pharmaceutical Co., Ltd, Jingmen 448000, Hubei, China
* Authors to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 15 January 2014 / Accepted: 15 January 2014 / Published: 21 January 2014
(This article belongs to the Section Organic Synthesis)
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Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.
Keywords: barnidipine hydrochloride; impurities; antihypertensive agent barnidipine hydrochloride; impurities; antihypertensive agent
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cheng, Z.-G.; Dai, X.-Y.; Li, L.-W.; Wan, Q.; Ma, X.; Xiang, G.-Y. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance. Molecules 2014, 19, 1344-1352.

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