Molecules 2014, 19(1), 1344-1352; doi:10.3390/molecules19011344
Article

Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

1,2email, 2email, 3email, 4email, 1,* email and 1,* email
Received: 11 December 2013; in revised form: 15 January 2014 / Accepted: 15 January 2014 / Published: 21 January 2014
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.
Keywords: barnidipine hydrochloride; impurities; antihypertensive agent
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MDPI and ACS Style

Cheng, Z.-G.; Dai, X.-Y.; Li, L.-W.; Wan, Q.; Ma, X.; Xiang, G.-Y. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance. Molecules 2014, 19, 1344-1352.

AMA Style

Cheng Z-G, Dai X-Y, Li L-W, Wan Q, Ma X, Xiang G-Y. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance. Molecules. 2014; 19(1):1344-1352.

Chicago/Turabian Style

Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya. 2014. "Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance." Molecules 19, no. 1: 1344-1352.

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