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Molecules 2014, 19(1), 1344-1352; doi:10.3390/molecules19011344
Article

Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

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1,*  and 1,*
1 School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Wuhan Biocause Pharmaceutical Development Co., Ltd, Wuhan 430056, Hubei, China 3 College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, Hubei, China 4 Hubei Biocause Heilen Pharmaceutical Co., Ltd, Jingmen 448000, Hubei, China
* Authors to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 15 January 2014 / Accepted: 15 January 2014 / Published: 21 January 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.
Keywords: barnidipine hydrochloride; impurities; antihypertensive agent barnidipine hydrochloride; impurities; antihypertensive agent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cheng, Z.-G.; Dai, X.-Y.; Li, L.-W.; Wan, Q.; Ma, X.; Xiang, G.-Y. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance. Molecules 2014, 19, 1344-1352.

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