Molecules 2014, 19(1), 1317-1327; doi:10.3390/molecules19011317

Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives

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Received: 7 November 2013; in revised form: 11 December 2013 / Accepted: 20 December 2013 / Published: 21 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3β-formyloxy-urs-12-en-28-oic acid at the concentration of 64 μg/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 μg/mL to 8 μg/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity.
Keywords: Sambucus australis; ursolic acid; antioxidant activity; antibacterial activity
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MDPI and ACS Style

do Nascimento, P.G.; Lemos, T.L.; Bizerra, A.M.; Arriaga, Â.M.; Ferreira, D.A.; Santiago, G.M.; Braz-Filho, R.; Costa, J.G.M. Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives. Molecules 2014, 19, 1317-1327.

AMA Style

do Nascimento PG, Lemos TL, Bizerra AM, Arriaga ÂM, Ferreira DA, Santiago GM, Braz-Filho R, Costa JGM. Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives. Molecules. 2014; 19(1):1317-1327.

Chicago/Turabian Style

do Nascimento, Patrícia G.; Lemos, Telma L.; Bizerra, Ayla M.; Arriaga, Ângela M.; Ferreira, Daniele A.; Santiago, Gilvandete M.; Braz-Filho, Raimundo; Costa, José G.M. 2014. "Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives." Molecules 19, no. 1: 1317-1327.

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