Molecules 2014, 19(1), 1223-1237; doi:10.3390/molecules19011223
Article

Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells

1email, 2email, 2,3email, 1,* email, 1email and 2email
Received: 9 December 2013; in revised form: 9 January 2014 / Accepted: 13 January 2014 / Published: 20 January 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Biphenyl neolignans such as honokiol and magnolol, which are the major active constituents of the Asian medicinal plant Magnolia officinalis, are known to exert a multitude of pharmacological and biological activities. Among these, cytotoxic and tumor growth inhibitory activity against various tumour cell lines are well-documented. To further elucidate the cytotoxic effects of honokiol derivatives, derivatizations were performed using tetrahydrohonokiol as a scaffold. The derivatizations comprised the introduction of functional groups, e.g., nitro and amino groups, as well as alkylation. This way, 18 derivatives, of which 13 were previously undescribed compounds, were evaluated against CCRF-CEM leukemia cells, U251 glioblastoma and HCT-116 colon cancer cells. The results revealed no significant cytotoxic effects in any of the three tested cell lines at a test concentration of 10 µM.
Keywords: tetrahydrohonokiol derivatives; cytotoxicity; CCRF-CEM leukemia cells; U251 glioblastoma; HCT-116 colon cancer cells; Magnolia officinalis
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MDPI and ACS Style

Bernaskova, M.; Kretschmer, N.; Schuehly, W.; Huefner, A.; Weis, R.; Bauer, R. Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells. Molecules 2014, 19, 1223-1237.

AMA Style

Bernaskova M, Kretschmer N, Schuehly W, Huefner A, Weis R, Bauer R. Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells. Molecules. 2014; 19(1):1223-1237.

Chicago/Turabian Style

Bernaskova, Marketa; Kretschmer, Nadine; Schuehly, Wolfgang; Huefner, Antje; Weis, Robert; Bauer, Rudolf. 2014. "Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells." Molecules 19, no. 1: 1223-1237.


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