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Molecules 2013, 18(9), 11601-11613; doi:10.3390/molecules180911601

Solution Properties and in Vitro Anti-Tumor Activities of Polysaccharides from Longan Pulp

Key Laboratory of Functional Food, Sericulture and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Author to whom correspondence should be addressed.
Received: 13 June 2013 / Revised: 28 August 2013 / Accepted: 11 September 2013 / Published: 18 September 2013
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The solution properties of four fractions (LPI–IV) from crude longan pulp polysaccharides (LP3) were analyzed by size-exclusion chromatography combined with laser light scattering, viscometry, complex formation with Congo red, and atomic force microscopy. Their radii of gyration (<S2>z1/2) were 43.3, 62.6, 43.2 and 77.3 nm, exponents of <S2>z1/2 = k Mwv were 0.04, 0.50, 0.52 and 0.02, and intrinsic viscosities ([η]) were 9.945, 25.38, 308.2 and 452.1 mL/g, respectively. Moreover, the dependence of [η] on Mw was established to be [η] = 5.3 × 10−2Mw0.61 (mL/g). LPI had both a sphere-like conformation and a triple-helix structure, and LPII–IV existed as flexible chains. LP3, LPI, LPII and LPIII all exhibited direct inhibitory effects on A549, HeLa and HepG2 cells in a positive dose-dependent manner in the range of 50–400 µg/mL. The activities of LPIII, especially the inhibition of HepG2 cell proliferation, were stronger than those of others, which may be partly related to its flexible conformation. The present results support the cancer therapeutic potential of longan polysaccharides. View Full-Text
Keywords: longan pulp; polysaccharide; solution property; conformation; anti-tumor activity longan pulp; polysaccharide; solution property; conformation; anti-tumor activity

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MDPI and ACS Style

Yi, Y.; Huang, F.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Wei, Z.-C.; He, J.-R. Solution Properties and in Vitro Anti-Tumor Activities of Polysaccharides from Longan Pulp. Molecules 2013, 18, 11601-11613.

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