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Molecules 2013, 18(9), 10912-10929; doi:10.3390/molecules180910912
Article

Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones

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Received: 14 August 2013; in revised form: 2 September 2013 / Accepted: 4 September 2013 / Published: 5 September 2013
(This article belongs to the Section Medicinal Chemistry)
Download PDF [322 KB, uploaded 18 June 2014]
Abstract: 2,4-Dimethylbenzoylhydrazones 130 were synthesized by condensation reactions of 2,4-dimethylbenzoylhydrazide with various aromatic aldehydes and characterized. The assigned structures of compounds 10, 15 and 22 were further supported by single-crystal X-ray diffraction data. The synthesized compounds were evaluated for their in vitro DPPH radical scavenging activity. They exerted varying degree of scavenging activity toward DPPH radical with IC50 values between 25.6–190 µM. Compounds 1, 4, 2, 3, 7, and 6 have IC50 values of 25.6, 28.1, 29.3, 29.8, 30.0 and 30.1 µM respectively, showing better activity than an n-propyl gallate standard (IC50 value = 30.30 µM). For super oxide anion scavenging activity compounds 1, 2 and 3 with IC50 values of 98.3, 102.6, and 105.6, respectively, also showed better activity than the n-propyl gallate standard (IC50 value = 106.34 µM).
Keywords: 2,4-dimethylbenzoylhydrazones; DPPH scavenging; superoxide ion scavenger; crystal structure 2,4-dimethylbenzoylhydrazones; DPPH scavenging; superoxide ion scavenger; crystal structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Taha, M.; Ismail, N.H.; Jamil, W.; Yousuf, S.; Jaafar, F.M.; Ali, M.I.; Kashif, S.M.; Hussain, E. Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones. Molecules 2013, 18, 10912-10929.

AMA Style

Taha M, Ismail NH, Jamil W, Yousuf S, Jaafar FM, Ali MI, Kashif SM, Hussain E. Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones. Molecules. 2013; 18(9):10912-10929.

Chicago/Turabian Style

Taha, Muhammad; Ismail, Nor H.; Jamil, Waqas; Yousuf, Sammer; Jaafar, Faridahanim M.; Ali, Muhammad I.; Kashif, Syed M.; Hussain, Ejaz. 2013. "Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones." Molecules 18, no. 9: 10912-10929.


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