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Molecules 2013, 18(9), 10768-10775; doi:10.3390/molecules180910768
Article

Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

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1 College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning, China 2 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 3 Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China 4 Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
* Authors to whom correspondence should be addressed.
Received: 27 June 2013 / Revised: 22 July 2013 / Accepted: 21 August 2013 / Published: 3 September 2013
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Abstract

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 46 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC50 values of 6.19 to 26.84 μg/mL.
Keywords: 8-geranyloxypsolaren; 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde; Clausena lansium; carbazoles; coumarins; cytotoxic activity 8-geranyloxypsolaren; 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde; Clausena lansium; carbazoles; coumarins; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiang, H.Y.; Wang, C.F.; Fan, L.; Yang, K.; Feng, J.B.; Geng, Z.F.; Xu, J.; Deng, Z.W.; Du, S.S.; Yin, H.B. Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels. Molecules 2013, 18, 10768-10775.

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