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Molecules 2013, 18(9), 10599-10608; doi:10.3390/molecules180910599
Article

Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative

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Received: 6 August 2013; in revised form: 21 August 2013 / Accepted: 28 August 2013 / Published: 2 September 2013
(This article belongs to the Section Metabolites)
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Abstract: Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. The major constituent α-mangostin was also checked for antimicrobial potential against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Bacillius subtilis, Staphylococcus aureus, Mycobacterium smegmatis, M. cheleneoi, M. xenopi and M. intracellulare. Activity against P. falciparum (IC50 2.7 μg/mL) and T. brucei (IC50 0.5 μg/mL) were observed for the dichloromethane extract, however, with only moderate selectivity was seen based on a parallel cytotoxicity evaluation on MRC-5 cells (IC50 9.4 μg/mL). The ethyl acetate extract was inactive (IC50 > 30 µg/mL). The major constituent α-mangostin showed rather high cytotoxicity (IC50 7.5 µM) and a broad but non-selective antiprotozoal and antimicrobial activity profile. This in vitro study endorses that the antiprotozoal and antimicrobial potential of prenylated xanthones is non-conclusive in view of the low level of selectivity.
Keywords: Garcinia mangostana; α-mangostin; in vitro; antiplasmodial; antileishmanial; antitrypanosomal Garcinia mangostana; α-mangostin; in vitro; antiplasmodial; antileishmanial; antitrypanosomal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Massarani, S.M.; El Gamal, A.A.; Al-Musayeib, N.M.; Mothana, R.A.; Basudan, O.A.; Al-Rehaily, A.J.; Farag, M.; Assaf, M.H.; El Tahir, K.H.; Maes, L. Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative. Molecules 2013, 18, 10599-10608.

AMA Style

Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, Farag M, Assaf MH, El Tahir KH, Maes L. Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative. Molecules. 2013; 18(9):10599-10608.

Chicago/Turabian Style

Al-Massarani, Shaza M.; El Gamal, Ali A.; Al-Musayeib, Nawal M.; Mothana, Ramzi A.; Basudan, Omer A.; Al-Rehaily, Adnan J.; Farag, Mohamed; Assaf, Mahmoud H.; El Tahir, KamalEldin H.; Maes, Louis. 2013. "Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative." Molecules 18, no. 9: 10599-10608.


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