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Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
Section of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway
Department of Traditional Medicine, Institut National de Recherche en Santé Publique, BP 1746, Bamako, Mali
* Authors to whom correspondence should be addressed.
Received: 3 July 2013; in revised form: 8 August 2013 / Accepted: 14 August 2013 / Published: 26 August 2013
Abstract: Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides.
Keywords: Biophytum umbraculum; flavone-C-glycosides; DPPH; xanthine oxidase; 15-lipoxygenase
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Pham, A.T.; Nguyen, C.; Malterud, K.E.; Diallo, D.; Wangensteen, H. Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum. Molecules 2013, 18, 10312-10319.
Pham AT, Nguyen C, Malterud KE, Diallo D, Wangensteen H. Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum. Molecules. 2013; 18(9):10312-10319.
Pham, Anh T.; Nguyen, Celine; Malterud, Karl E.; Diallo, Drissa; Wangensteen, Helle. 2013. "Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum." Molecules 18, no. 9: 10312-10319.