Molecules 2013, 18(8), 9770-9784; doi:10.3390/molecules18089770
Article

Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

1email, 2email, 1email, 2,3email, 2email, 4email, 5email, 2email and 1,* email
Received: 17 June 2013; in revised form: 2 August 2013 / Accepted: 9 August 2013 / Published: 15 August 2013
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract. Four alkaloids—vindoline I, vindolidine II, vindolicine III and vindolinine IV—were isolated and identified from the dichloromethane extract (DE) of this plant’s leaves. DE and compounds IIII were not cytotoxic towards pancreatic β-TC6 cells at the highest dosage tested (25.0 µg/mL). All four alkaloids induced relatively high glucose uptake in pancreatic β-TC6 or myoblast C2C12 cells, with III showing the highest activity. In addition, compounds IIIV demonstrated good protein tyrosine phosphatase-1B (PTP-1B) inhibition activity, implying their therapeutic potential against type 2 diabetes. III showed the highest antioxidant potential in ORAC and DPPH assays and it also alleviated H2O2-induced oxidative damage in β-TC6 cells at 12.5 µg/mL and 25.0 µg/mL.
Keywords: Catharanthus roseus; alkaloids; β-TC6; C2C12; cytotoxicity; antioxidant; glucose uptake; PTP-1B
PDF Full-text Download PDF Full-Text [1758 KB, uploaded 18 June 2014 20:10 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Tiong, S.H.; Looi, C.Y.; Hazni, H.; Arya, A.; Paydar, M.; Wong, W.F.; Cheah, S.-C.; Mustafa, M.R.; Awang, K. Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don. Molecules 2013, 18, 9770-9784.

AMA Style

Tiong SH, Looi CY, Hazni H, Arya A, Paydar M, Wong WF, Cheah S-C, Mustafa MR, Awang K. Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don. Molecules. 2013; 18(8):9770-9784.

Chicago/Turabian Style

Tiong, Soon H.; Looi, Chung Y.; Hazni, Hazrina; Arya, Aditya; Paydar, Mohammadjavad; Wong, Won F.; Cheah, Shiau-Chuen; Mustafa, Mohd R.; Awang, Khalijah. 2013. "Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don." Molecules 18, no. 8: 9770-9784.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert