Molecules 2013, 18(8), 8994-9009; doi:10.3390/molecules18088994
Article

Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activities

1 Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Centre for Foundation Studies in Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia 4 Medical Research Center, Faculty of Medicine, Jazan University, Jazan 45041, Saudi Arabia
* Authors to whom correspondence should be addressed.
Received: 16 May 2013; in revised form: 16 July 2013 / Accepted: 22 July 2013 / Published: 29 July 2013
(This article belongs to the Section Natural Products)
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Abstract: The oxoaporphine alkaloid lysicamine (1), and three proaporphine alkaloids, litsericinone (2), 8,9,11,12-tetrahydromecambrine (3) and hexahydromecambrine A (4) were isolated from the leaves of Phoebe grandis (Nees) Merr. (Lauraceae). Compounds 2 and 3 were first time isolated as new naturally occurring compounds from plants. The NMR data for the compounds 24 have never been reported so far. Compounds 1 and 2 showed significant cytotoxic activity against a MCF7 (human estrogen receptor (ER+) positive breast cancer) cell line with IC50 values of 26 and 60 µg/mL, respectively. Furthermore, in vitro cytotoxic activity against HepG2 (human liver cancer) cell line was evaluated for compounds 14 with IC50 values of 27, 14, 81 and 20 µg/mL, respectively. Lysicamine (1) displayed strong antibacterial activity against Bacillus subtilis (B145), Staphylococcus aureus (S1434) and Staphylococus epidermidis (a clinically isolated strain) with inhibition zones of 15.50 ± 0.57, 13.33 ± 0.57 and 12.00 ± 0.00 mm, respectively. However, none of the tested pathogenic bacteria were susceptible towards compounds 2 and 3.
Keywords: Phoebe grandis; Lauraceae; aporphine alkaloid; cytotoxic; antibacterial

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MDPI and ACS Style

Omar, H.; Hashim, N.M.; Zajmi, A.; Nordin, N.; Abdelwahab, S.I.; Azizan, A.H.S.; Hadi, A.H.A.; Ali, H.M. Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activities. Molecules 2013, 18, 8994-9009.

AMA Style

Omar H, Hashim NM, Zajmi A, Nordin N, Abdelwahab SI, Azizan AHS, Hadi AHA, Ali HM. Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activities. Molecules. 2013; 18(8):8994-9009.

Chicago/Turabian Style

Omar, Hanita; Hashim, Najihah M.; Zajmi, Asdren; Nordin, Noraziah; Abdelwahab, Siddiq I.; Azizan, Ainnul H.S.; Hadi, A. H.A.; Ali, Hapipah M. 2013. "Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activities." Molecules 18, no. 8: 8994-9009.

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