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Molecules 2013, 18(6), 7058-7070; doi:10.3390/molecules18067058
Article

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

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Received: 6 May 2013; in revised form: 6 June 2013 / Accepted: 7 June 2013 / Published: 17 June 2013
(This article belongs to the Section Organic Synthesis)
Download PDF [694 KB, uploaded 18 June 2014]
Abstract: Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
Keywords: antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Brand, G.D.; Santos, R.C.; Arake, L.M.; Silva, V.G.; Veras, L.M.C.; Costa, V.; Costa, C.H.N.; Kuckelhaus, S.S.; Alexandre, J.G.; Feio, M.J.; Leite, J.R.S.A. The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides. Molecules 2013, 18, 7058-7070.

AMA Style

Brand GD, Santos RC, Arake LM, Silva VG, Veras LMC, Costa V, Costa CHN, Kuckelhaus SS, Alexandre JG, Feio MJ, Leite JRSA. The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides. Molecules. 2013; 18(6):7058-7070.

Chicago/Turabian Style

Brand, Guilherme D.; Santos, Raimunda C.; Arake, Luisa M.; Silva, Valdelânia G.; Veras, Leiz M.C.; Costa, Vladimir; Costa, Carlos H.N.; Kuckelhaus, Selma S.; Alexandre, José G.; Feio, Maria J.; Leite, José R.S.A. 2013. "The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides." Molecules 18, no. 6: 7058-7070.


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