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Molecules 2013, 18(6), 7058-7070; doi:10.3390/molecules18067058
Article

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

1,2,3
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 and 2,*
1 Laboratório de Espectrometria de Massa, EMBRAPA, Recursos Genéticos e Biotecnologia, Brasília, DF 70770-900, Brazil 2 Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Parnaíba, Universidade Federal do Piauí, UFPI, Parnaiba, PI 64202-320, Brazil 3 Bolsista de Desenvolvimento Científico Regional, DCR, FAPEPI/CNPq, Campus Parnaíba, Universidade Federal do Piauí, UFPI, Parnaiba, PI 64202-320, Brazil 4 Programa de Doutorado em Biotecnologia, RENORBIO, Universidade Federal do Piauí, UFPI, Teresina, PI 64001-020, Brazil 5 Laboratório de Pesquisas em Leishmanioses, Instituto de Doenças Tropicais Natan Portela, IDTNP, Teresina, PI, 64001-450, Brazil 6 Laboratório de Imunologia Celular, Área de Patologia, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília, DF 70910-900, Brazil 7 REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 4169-007 Porto, Portugal
* Author to whom correspondence should be addressed.
Received: 6 May 2013 / Revised: 6 June 2013 / Accepted: 7 June 2013 / Published: 17 June 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
Keywords: antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Brand, G.D.; Santos, R.C.; Arake, L.M.; Silva, V.G.; Veras, L.M.C.; Costa, V.; Costa, C.H.N.; Kuckelhaus, S.S.; Alexandre, J.G.; Feio, M.J.; Leite, J.R.S.A. The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides. Molecules 2013, 18, 7058-7070.

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