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Molecules 2013, 18(6), 6898-6907; doi:10.3390/molecules18066898

Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum

1
Laboratory of Natural Products, Faculty of Science and Center for Innovation in Chemistry, Lampang Rajabhat University, Lampang 52100, Thailand
2
Department of Chemistry, Faculty of Science and Center for Innovation in Chemistry, Chiang Mai University, Chiang Mai 50300, Thailand
3
Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50300, Thailand
4
The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand
*
Author to whom correspondence should be addressed.
Received: 8 May 2013 / Revised: 30 May 2013 / Accepted: 7 June 2013 / Published: 10 June 2013
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Abstract

A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone. View Full-Text
Keywords: dihydrochalcone; antiinflammatory activity; Cyathostemma argenteum; annonaceae dihydrochalcone; antiinflammatory activity; Cyathostemma argenteum; annonaceae
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Somsrisa, J.; Meepowpan, P.; Krachodnok, S.; Thaisuchat, H.; Punyanitya, S.; Nantasaen, N.; Pompimon, W. Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum. Molecules 2013, 18, 6898-6907.

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