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Molecules 2013, 18(6), 6898-6907; doi:10.3390/molecules18066898
Article

Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum

1
, 2
, 1
, 1
, 3
, 4
 and 1,*
Received: 8 May 2013; in revised form: 30 May 2013 / Accepted: 7 June 2013 / Published: 10 June 2013
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Abstract: A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.
Keywords: dihydrochalcone; antiinflammatory activity; Cyathostemma argenteum; annonaceae dihydrochalcone; antiinflammatory activity; Cyathostemma argenteum; annonaceae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Somsrisa, J.; Meepowpan, P.; Krachodnok, S.; Thaisuchat, H.; Punyanitya, S.; Nantasaen, N.; Pompimon, W. Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum. Molecules 2013, 18, 6898-6907.

AMA Style

Somsrisa J, Meepowpan P, Krachodnok S, Thaisuchat H, Punyanitya S, Nantasaen N, Pompimon W. Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum. Molecules. 2013; 18(6):6898-6907.

Chicago/Turabian Style

Somsrisa, Jariya; Meepowpan, Puttinan; Krachodnok, Samroeng; Thaisuchat, Haruthai; Punyanitya, Sittiporn; Nantasaen, Narong; Pompimon, Wilart. 2013. "Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum." Molecules 18, no. 6: 6898-6907.



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