Molecules 2013, 18(6), 6153-6160; doi:10.3390/molecules18066153
Article

Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities

1 State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China 2 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China 3 Sichuan Wan'an Dendrobe Industry Development Co., Ltd., Chengdu 610072, Sichuan, China
* Authors to whom correspondence should be addressed.
Received: 15 April 2013; in revised form: 16 May 2013 / Accepted: 20 May 2013 / Published: 23 May 2013
(This article belongs to the Section Natural Products)
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Abstract: A new 8,4¢-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2-7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (–)-(7S,8R,7¢E)-4-hydroxy-3,3¢,5,5¢-tetramethoxy-8,4¢-oxyneolign-7¢-ene-7,9,9¢-triol 7,9¢-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (-)-syringaresinol-4,4¢-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC50 value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
Keywords: Dendrobium aurantiacum var. denneanum; lignan glucosides; phenylpropanoid glycosides; bioactivities

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MDPI and ACS Style

Xiong, L.; Cao, Z.-X.; Peng, C.; Li, X.-H.; Xie, X.-F.; Zhang, T.-M.; Zhou, Q.-M.; Yang, L.; Guo, L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules 2013, 18, 6153-6160.

AMA Style

Xiong L, Cao Z-X, Peng C, Li X-H, Xie X-F, Zhang T-M, Zhou Q-M, Yang L, Guo L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules. 2013; 18(6):6153-6160.

Chicago/Turabian Style

Xiong, Liang; Cao, Zhi-Xing; Peng, Cheng; Li, Xiao-Hong; Xie, Xiao-Fang; Zhang, Ting-Mo; Zhou, Qin-Mei; Yang, Lian; Guo, Li. 2013. "Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities." Molecules 18, no. 6: 6153-6160.

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