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Molecules 2013, 18(6), 6153-6160; doi:10.3390/molecules18066153
Article

Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities

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Received: 15 April 2013; in revised form: 16 May 2013 / Accepted: 20 May 2013 / Published: 23 May 2013
(This article belongs to the Section Metabolites)
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Abstract: A new 8,4¢-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2-7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (–)-(7S,8R,7¢E)-4-hydroxy-3,3¢,5,5¢-tetramethoxy-8,4¢-oxyneolign-7¢-ene-7,9,9¢-triol 7,9¢-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (-)-syringaresinol-4,4¢-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC50 value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
Keywords: Dendrobium aurantiacum var. denneanum; lignan glucosides; phenylpropanoid glycosides; bioactivities Dendrobium aurantiacum var. denneanum; lignan glucosides; phenylpropanoid glycosides; bioactivities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xiong, L.; Cao, Z.-X.; Peng, C.; Li, X.-H.; Xie, X.-F.; Zhang, T.-M.; Zhou, Q.-M.; Yang, L.; Guo, L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules 2013, 18, 6153-6160.

AMA Style

Xiong L, Cao Z-X, Peng C, Li X-H, Xie X-F, Zhang T-M, Zhou Q-M, Yang L, Guo L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules. 2013; 18(6):6153-6160.

Chicago/Turabian Style

Xiong, Liang; Cao, Zhi-Xing; Peng, Cheng; Li, Xiao-Hong; Xie, Xiao-Fang; Zhang, Ting-Mo; Zhou, Qin-Mei; Yang, Lian; Guo, Li. 2013. "Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities." Molecules 18, no. 6: 6153-6160.


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