Abstract: A new 8,4¢-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2-7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (–)-(7S,8R,7¢E)-4-hydroxy-3,3¢,5,5¢-tetramethoxy-8,4¢-oxyneolign-7¢-ene-7,9,9¢-triol 7,9¢-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (-)-syringaresinol-4,4¢-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC50 value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
Keywords: Dendrobium aurantiacum var. denneanum; lignan glucosides; phenylpropanoid glycosides; bioactivities
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Xiong, L.; Cao, Z.-X.; Peng, C.; Li, X.-H.; Xie, X.-F.; Zhang, T.-M.; Zhou, Q.-M.; Yang, L.; Guo, L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules 2013, 18, 6153-6160.
Xiong L, Cao Z-X, Peng C, Li X-H, Xie X-F, Zhang T-M, Zhou Q-M, Yang L, Guo L. Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities. Molecules. 2013; 18(6):6153-6160.
Xiong, Liang; Cao, Zhi-Xing; Peng, Cheng; Li, Xiao-Hong; Xie, Xiao-Fang; Zhang, Ting-Mo; Zhou, Qin-Mei; Yang, Lian; Guo, Li. 2013. "Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities." Molecules 18, no. 6: 6153-6160.