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Characterization of Phenolic Constituents from Ephedra Herb Extract
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Department of Clinical Research, Oriental Medicine Research Center of Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
* Author to whom correspondence should be addressed.
Received: 18 March 2013; in revised form: 30 April 2013 / Accepted: 3 May 2013 / Published: 10 May 2013
Abstract: Nine known compounds: trans-cinnamic acid, catechin, syringin, epicatechin, symplocoside, kaempferol 3-O-rhamnoside 7-O-glucoside, isovitexin 2-O-rhamnoside, herbacetin 7-O-glucoside, and pollenitin B and a new flavonoid glycoside, characterized as herbacetin 7-O-neohesperidoside (1) on the basis of spectroscopic analysis and chemical evidence, were isolated from a traditional crude drug, “Ephedra herb extract”. Compound 1 had no effects on HGF-induced motility, whereas herbacetin, which is an aglycone of 1, significantly inhibited it.
Keywords: Ephedra herb; herbacetin 7-O-neohesperidoside; phenolics; Mao; Kampo
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Amakura, Y.; Yoshimura, M.; Yamakami, S.; Yoshida, T.; Wakana, D.; Hyuga, M.; Hyuga, S.; Hanawa, T.; Goda, Y. Characterization of Phenolic Constituents from Ephedra Herb Extract. Molecules 2013, 18, 5326-5334.
Amakura Y, Yoshimura M, Yamakami S, Yoshida T, Wakana D, Hyuga M, Hyuga S, Hanawa T, Goda Y. Characterization of Phenolic Constituents from Ephedra Herb Extract. Molecules. 2013; 18(5):5326-5334.
Amakura, Yoshiaki; Yoshimura, Morio; Yamakami, Saori; Yoshida, Takashi; Wakana, Daigo; Hyuga, Masashi; Hyuga, Sumiko; Hanawa, Toshihiko; Goda, Yukihiro. 2013. "Characterization of Phenolic Constituents from Ephedra Herb Extract." Molecules 18, no. 5: 5326-5334.