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Molecules 2013, 18(5), 5326-5334; doi:10.3390/molecules18055326
Article

Characterization of Phenolic Constituents from Ephedra Herb Extract

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1 Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan 2 Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan 3 Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan 4 Department of Clinical Research, Oriental Medicine Research Center of Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
* Author to whom correspondence should be addressed.
Received: 18 March 2013 / Revised: 30 April 2013 / Accepted: 3 May 2013 / Published: 10 May 2013
(This article belongs to the Section Natural Products)
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Abstract

Nine known compounds: trans-cinnamic acid, catechin, syringin, epicatechin, symplocoside, kaempferol 3-O-rhamnoside 7-O-glucoside, isovitexin 2-O-rhamnoside, herbacetin 7-O-glucoside, and pollenitin B and a new flavonoid glycoside, characterized as herbacetin 7-O-neohesperidoside (1) on the basis of spectroscopic analysis and chemical evidence, were isolated from a traditional crude drug, “Ephedra herb extract”. Compound 1 had no effects on HGF-induced motility, whereas herbacetin, which is an aglycone of 1, significantly inhibited it.
Keywords: Ephedra herb; herbacetin 7-O-neohesperidoside; phenolics; Mao; Kampo Ephedra herb; herbacetin 7-O-neohesperidoside; phenolics; Mao; Kampo
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Amakura, Y.; Yoshimura, M.; Yamakami, S.; Yoshida, T.; Wakana, D.; Hyuga, M.; Hyuga, S.; Hanawa, T.; Goda, Y. Characterization of Phenolic Constituents from Ephedra Herb Extract. Molecules 2013, 18, 5326-5334.

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