Molecules 2013, 18(5), 5190-5200; doi:10.3390/molecules18055190
Article

The Short-Term Effects of Soybean Intake on Oxidative and Carbonyl Stress in Men and Women

1 Institute of Molecular Biomedicine, Comenius University, Bratislava 811 08, Slovakia 2 Institute of Pathophysiology, Comenius University, Bratislava 811 08, Slovakia 3 Department of Molecular Biology, Comenius University, Bratislava 811 08, Slovakia 4 Institute of Physiology, Comenius University, Bratislava 811 08, Slovakia 5 Institute of Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Bratislava 811 08, Slovakia
* Author to whom correspondence should be addressed.
Received: 4 February 2013; in revised form: 19 March 2013 / Accepted: 25 April 2013 / Published: 7 May 2013
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Abstract: Beyond other beneficial effects, a soy-rich diet has been shown to reduce the risk of cardiovascular diseases and diabetic complications. Reduction of oxidative and carbonyl stress has been proposed as the underlying mechanism, but the evidence for this is lacking. The aim of our study was to evaluate the effects of short-term increased soy intake on oxidative and carbonyl stress parameters in young volunteers. Young healthy probands (omnivores) of both genders (55 women, 33 men) were given soybeans (2 g/kg bodyweight daily) for one week. Markers of oxidative and carbonyl stress were measured in plasma at the beginning and at the end of one week soybean intake and after another week of a wash-out period. Total antioxidant capacity was increased by soybean intake in both genders. This led to decreased levels of advanced oxidation protein products in women, but not in men. On the contrary, in men, soybean intake increased lipoperoxidation. No effects on carbonyl stress markers (advanced glycation end products-specific fluorescence and fructosamine) were found. Soybean intake has gender-specific effects on oxidative stress in young healthy probands potentially due to divergent action and metabolism of phytoestrogens in men and women. Effects of soybean intake on carbonyl stress should be evaluated in longer studies.
Keywords: soy; phytoestrogens; AOPP; AGEs; antioxidative status

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MDPI and ACS Style

Celec, P.; Hodosy, J.; Pálffy, R.; Gardlík, R.; Halčák, L.; Ostatníková, D. The Short-Term Effects of Soybean Intake on Oxidative and Carbonyl Stress in Men and Women. Molecules 2013, 18, 5190-5200.

AMA Style

Celec P, Hodosy J, Pálffy R, Gardlík R, Halčák L, Ostatníková D. The Short-Term Effects of Soybean Intake on Oxidative and Carbonyl Stress in Men and Women. Molecules. 2013; 18(5):5190-5200.

Chicago/Turabian Style

Celec, Peter; Hodosy, Július; Pálffy, Roland; Gardlík, Roman; Halčák, Lukáč; Ostatníková, Daniela. 2013. "The Short-Term Effects of Soybean Intake on Oxidative and Carbonyl Stress in Men and Women." Molecules 18, no. 5: 5190-5200.

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