Molecules 2013, 18(4), 4718-4727; doi:10.3390/molecules18044718
Article

New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities

1,* email, 2,3, 1, 1, 4,5, 1, 4,5 and 1
Received: 26 March 2013; in revised form: 11 April 2013 / Accepted: 18 April 2013 / Published: 22 April 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position.
Keywords: quinoxaline; 1,4-di-N-oxide; leishmanicidal; antiplasmodial
PDF Full-text Download PDF Full-Text [192 KB, Updated Version, uploaded 18 June 2014 20:04 CEST]
The original version is still available [192 KB, uploaded 18 June 2014 20:04 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Barea, C.; Pabón, A.; Pérez-Silanes, S.; Galiano, S.; Gonzalez, G.; Monge, A.; Deharo, E.; Aldana, I. New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities. Molecules 2013, 18, 4718-4727.

AMA Style

Barea C, Pabón A, Pérez-Silanes S, Galiano S, Gonzalez G, Monge A, Deharo E, Aldana I. New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities. Molecules. 2013; 18(4):4718-4727.

Chicago/Turabian Style

Barea, Carlos; Pabón, Adriana; Pérez-Silanes, Silvia; Galiano, Silvia; Gonzalez, German; Monge, Antonio; Deharo, Eric; Aldana, Ignacio. 2013. "New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities." Molecules 18, no. 4: 4718-4727.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert