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Molecules 2013, 18(4), 4477-4486; doi:10.3390/molecules18044477

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

3, 1
4, 5 and 4,*
1 Department of Chemistry, Vinh University, Vinh 42000, Vietnam 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan 4 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 5 Department of Natural Science, Hong Duc University, Thanhhoa 41000, Vietnam These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 January 2013 / Revised: 3 April 2013 / Accepted: 12 April 2013 / Published: 16 April 2013
(This article belongs to the Section Metabolites)
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In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
Keywords: Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thang, T.D.; Kuo, P.-C.; Huang, G.-J.; Hung, N.H.; Huang, B.-S.; Yang, M.-L.; Luong, N.X.; Wu, T.-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules 2013, 18, 4477-4486.

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