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Molecules 2013, 18(4), 4477-4486; doi:10.3390/molecules18044477
Article

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

1,†
, 2,†
, 3, 1
, 2
, 4, 5 and 4,*
Received: 24 January 2013; in revised form: 3 April 2013 / Accepted: 12 April 2013 / Published: 16 April 2013
(This article belongs to the Section Metabolites)
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Abstract: In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
Keywords: Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Thang, T.D.; Kuo, P.-C.; Huang, G.-J.; Hung, N.H.; Huang, B.-S.; Yang, M.-L.; Luong, N.X.; Wu, T.-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules 2013, 18, 4477-4486.

AMA Style

Thang TD, Kuo P-C, Huang G-J, Hung NH, Huang B-S, Yang M-L, Luong NX, Wu T-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules. 2013; 18(4):4477-4486.

Chicago/Turabian Style

Thang, Tran D.; Kuo, Ping-Chung; Huang, Guan-Jhong; Hung, Nguyen H.; Huang, Bow-Shin; Yang, Mei-Lin; Luong, Ngo X.; Wu, Tian-Shung. 2013. "Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production." Molecules 18, no. 4: 4477-4486.


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