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Molecules 2013, 18(4), 4477-4486; doi:10.3390/molecules18044477
Article

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

1,†
,
2,†
,
3, 1
,
2
,
4, 5 and 4,*
1 Department of Chemistry, Vinh University, Vinh 42000, Vietnam 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan 4 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 5 Department of Natural Science, Hong Duc University, Thanhhoa 41000, Vietnam These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 January 2013 / Revised: 3 April 2013 / Accepted: 12 April 2013 / Published: 16 April 2013
(This article belongs to the Section Natural Products)
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Abstract

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
Keywords: Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Thang, T.D.; Kuo, P.-C.; Huang, G.-J.; Hung, N.H.; Huang, B.-S.; Yang, M.-L.; Luong, N.X.; Wu, T.-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules 2013, 18, 4477-4486.

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