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Molecules 2013, 18(3), 2895-2903; doi:10.3390/molecules18032895
Article

A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

1,2,†
, 3
, 3,†
, 4
, 1,2
, 1,2,5
, 2,5
, 1,2
, 2,6
, 2
, 5,6
, 5,6
, 5,6,*  and 1,2,5,7,*
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 6 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 February 2013 / Revised: 27 February 2013 / Accepted: 28 February 2013 / Published: 4 March 2013
(This article belongs to the Section Metabolites)
Download PDF [233 KB, 18 June 2014; original version 18 June 2014]

Abstract

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 13 towards various tumor cells is reported.
Keywords: Sinularia; epidioxysterol; cytotoxicity Sinularia; epidioxysterol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yen, W.-H.; Chen, W.-F.; Cheng, C.-H.; Dai, C.-F.; Lu, M.-C.; Su, J.-H.; Su, Y.-D.; Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Sheu, J.-H.; Lin, C.-S.; Wen, Z.-H.; Sung, P.-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules 2013, 18, 2895-2903.

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