Molecules 2013, 18(3), 2895-2903; doi:10.3390/molecules18032895
Article

A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

Wei-Hsuan Yen 1,2,† email, Wu-Fu Chen 3 email, Ching-Hsiao Cheng 3,† email, Chang-Feng Dai 4 email, Mei-Chin Lu 1,2 email, Jui-Hsin Su 1,2,5 email, Yin-Di Su 2,5 email, Yu-Hsin Chen 1,2 email, Yu-Chia Chang 2,6 email, Yung-Husan Chen 2 email, Jyh-Horng Sheu 5,6 email, Chan-Shing Lin 5,6 email, Zhi-Hong Wen 5,6,* email and Ping-Jyun Sung 1,2,5,7,* email
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 6 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 February 2013; in revised form: 27 February 2013 / Accepted: 28 February 2013 / Published: 4 March 2013
(This article belongs to the Section Natural Products)
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Abstract: A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported.
Keywords: Sinularia; epidioxysterol; cytotoxicity

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Cite This Article

MDPI and ACS Style

Yen, W.-H.; Chen, W.-F.; Cheng, C.-H.; Dai, C.-F.; Lu, M.-C.; Su, J.-H.; Su, Y.-D.; Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Sheu, J.-H.; Lin, C.-S.; Wen, Z.-H.; Sung, P.-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules 2013, 18, 2895-2903.

AMA Style

Yen W-H, Chen W-F, Cheng C-H, Dai C-F, Lu M-C, Su J-H, Su Y-D, Chen Y-H, Chang Y-C, Chen Y-H, Sheu J-H, Lin C-S, Wen Z-H, Sung P-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules. 2013; 18(3):2895-2903.

Chicago/Turabian Style

Yen, Wei-Hsuan; Chen, Wu-Fu; Cheng, Ching-Hsiao; Dai, Chang-Feng; Lu, Mei-Chin; Su, Jui-Hsin; Su, Yin-Di; Chen, Yu-Hsin; Chang, Yu-Chia; Chen, Yung-Husan; Sheu, Jyh-Horng; Lin, Chan-Shing; Wen, Zhi-Hong; Sung, Ping-Jyun. 2013. "A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli." Molecules 18, no. 3: 2895-2903.

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