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A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 February 2013; in revised form: 27 February 2013 / Accepted: 28 February 2013 / Published: 4 March 2013
Abstract: A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported.
Keywords: Sinularia; epidioxysterol; cytotoxicity
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Yen, W.-H.; Chen, W.-F.; Cheng, C.-H.; Dai, C.-F.; Lu, M.-C.; Su, J.-H.; Su, Y.-D.; Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Sheu, J.-H.; Lin, C.-S.; Wen, Z.-H.; Sung, P.-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules 2013, 18, 2895-2903.
Yen W-H, Chen W-F, Cheng C-H, Dai C-F, Lu M-C, Su J-H, Su Y-D, Chen Y-H, Chang Y-C, Chen Y-H, Sheu J-H, Lin C-S, Wen Z-H, Sung P-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules. 2013; 18(3):2895-2903.
Yen, Wei-Hsuan; Chen, Wu-Fu; Cheng, Ching-Hsiao; Dai, Chang-Feng; Lu, Mei-Chin; Su, Jui-Hsin; Su, Yin-Di; Chen, Yu-Hsin; Chang, Yu-Chia; Chen, Yung-Husan; Sheu, Jyh-Horng; Lin, Chan-Shing; Wen, Zhi-Hong; Sung, Ping-Jyun. 2013. "A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli." Molecules 18, no. 3: 2895-2903.