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Molecules 2013, 18(3), 2895-2903; doi:10.3390/molecules18032895
Article

A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

1,2,†
,
3
,
3,†
,
4
,
1,2
,
1,2,5
,
2,5
,
1,2
,
2,6
,
2
,
5,6
,
5,6
,
5,6,*  and 1,2,5,7,*
Received: 5 February 2013 / Revised: 27 February 2013 / Accepted: 28 February 2013 / Published: 4 March 2013
(This article belongs to the Section Metabolites)
Download PDF [233 KB, 18 June 2014; original version 18 June 2014]

Abstract

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 13 towards various tumor cells is reported.
Keywords: Sinularia; epidioxysterol; cytotoxicity Sinularia; epidioxysterol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yen, W.-H.; Chen, W.-F.; Cheng, C.-H.; Dai, C.-F.; Lu, M.-C.; Su, J.-H.; Su, Y.-D.; Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Sheu, J.-H.; Lin, C.-S.; Wen, Z.-H.; Sung, P.-J. A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli. Molecules 2013, 18, 2895-2903.

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