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Molecules 2013, 18(3), 2754-2762; doi:10.3390/molecules18032754
Article

Insecticidal and Feeding Deterrent Effects of Fraxinellone from Dictamnus dasycarpus against Four Major Pests

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Received: 5 December 2012; in revised form: 29 January 2013 / Accepted: 6 February 2013 / Published: 1 March 2013
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Abstract: Fraxinellone, a well-known and significant naturally occurring compound isolated from Meliaceae and Rutaceae spp. has been widely used as a drug for the treatment of tumors. On the other hand, fraxinellone exhibited a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. The present study focused on the antifeedant and larvicidal activities of fraxinellone against the larvae of Lepidoptera, including Mythimna separata, Agrotis ypsilon, Plutella xylostella, and one kind of sanitary pest, Culux pipiens pallens. Meanwhile, the ovicidal activities and the effects of fraxinellone on the larval development of M. separata were also observed. The LC50 values of fraxinellone against 3rd instar larvae of M. separata, 2nd instar larvae of P. xylostella and 4th instar larvae of C. pipiens pallens were 15.95/6.43/3.60 × 10−2 mg mL1, and its AFC50 values against 5th instar larvae of M. separata, 2nd instar larvae of P. xylostella and 2nd instar larvae of A. ypsilon were 10.73/7.93/12.58 mg mL−1, respectively. Compared with the control group, fraxinellone obviously inhibited the pupation rate and the growth of M. separata. Once M. separata was treated with fraxinellone at concentrations of 5.0, 10.0, and 20.0 mg mL−1, respectively, the stages from the larvae to adulthood and the egg hatching duration were prolonged to 1/2/3, and 4/3/4 days, respectively. Additionally, fraxinellone strongly inhibited the development rate and the egg hatch proportion of M. separata.
Keywords: fraxinellone; antifeedant activity; ovicidal action; development change fraxinellone; antifeedant activity; ovicidal action; development change
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lü, M.; Wu, W.; Liu, H. Insecticidal and Feeding Deterrent Effects of Fraxinellone from Dictamnus dasycarpus against Four Major Pests. Molecules 2013, 18, 2754-2762.

AMA Style

Lü M, Wu W, Liu H. Insecticidal and Feeding Deterrent Effects of Fraxinellone from Dictamnus dasycarpus against Four Major Pests. Molecules. 2013; 18(3):2754-2762.

Chicago/Turabian Style

Lü, Min; Wu, Wenjun; Liu, Huixia. 2013. "Insecticidal and Feeding Deterrent Effects of Fraxinellone from Dictamnus dasycarpus against Four Major Pests." Molecules 18, no. 3: 2754-2762.


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