Abstract: Four pyrazole compounds, 3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde (1), 5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde (2), 1-[5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone (3) and 1-[3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one (4), have been prepared by condensing chalcones with hydrazine hydrate in the presence of aliphatic acids, namely formic acid, acetic acid and propionic acid. The structures were characterized by X-ray single crystal structure determination. The dihedral angles formed between the pyrazole and the fluoro-substituted rings are 4.64(7)° in 1, 5.3(4)° in 2 and 4.89(6)° in 3. In 4, the corresponding angles for molecules A and molecules B are 10.53(10)° and 9.78(10)°, respectively.
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Loh, W.-S.; Quah, C.K.; Chia, T.S.; Fun, H.-K.; Sapnakumari, M.; Narayana, B.; Sarojini, B.K. Synthesis and Crystal Structures of N-Substituted Pyrazolines. Molecules 2013, 18, 2386-2396.
Loh W-S, Quah CK, Chia TS, Fun H-K, Sapnakumari M, Narayana B, Sarojini BK. Synthesis and Crystal Structures of N-Substituted Pyrazolines. Molecules. 2013; 18(2):2386-2396.
Loh, Wan-Sin; Quah, Ching K.; Chia, Tze S.; Fun, Hoong-Kun; Sapnakumari, Majal; Narayana, Badiadka; Sarojini, Balladka K. 2013. "Synthesis and Crystal Structures of N-Substituted Pyrazolines." Molecules 18, no. 2: 2386-2396.