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Molecules 2013, 18(2), 2386-2396; doi:10.3390/molecules18022386

Synthesis and Crystal Structures of N-Substituted Pyrazolines

1, 1, 1, 1,2,* , 3, 3 and 4
Received: 12 December 2012 / Revised: 2 February 2013 / Accepted: 7 February 2013 / Published: 20 February 2013
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Abstract: Four pyrazole compounds, 3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde (1), 5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde (2), 1-[5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone (3) and 1-[3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one (4), have been prepared by condensing chalcones with hydrazine hydrate in the presence of aliphatic acids, namely formic acid, acetic acid and propionic acid. The structures were characterized by X-ray single crystal structure determination. The dihedral angles formed between the pyrazole and the fluoro-substituted rings are 4.64(7)° in 1, 5.3(4)° in 2 and 4.89(6)° in 3. In 4, the corresponding angles for molecules A and molecules B are 10.53(10)° and 9.78(10)°, respectively.
Keywords: synthesis; X-ray diffraction; pyrazole; crystal structure synthesis; X-ray diffraction; pyrazole; crystal structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Loh, W.-S.; Quah, C.K.; Chia, T.S.; Fun, H.-K.; Sapnakumari, M.; Narayana, B.; Sarojini, B.K. Synthesis and Crystal Structures of N-Substituted Pyrazolines. Molecules 2013, 18, 2386-2396.

AMA Style

Loh W-S, Quah CK, Chia TS, Fun H-K, Sapnakumari M, Narayana B, Sarojini BK. Synthesis and Crystal Structures of N-Substituted Pyrazolines. Molecules. 2013; 18(2):2386-2396.

Chicago/Turabian Style

Loh, Wan-Sin; Quah, Ching K.; Chia, Tze S.; Fun, Hoong-Kun; Sapnakumari, Majal; Narayana, Badiadka; Sarojini, Balladka K. 2013. "Synthesis and Crystal Structures of N-Substituted Pyrazolines." Molecules 18, no. 2: 2386-2396.

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