Next Article in Journal
7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies
Previous Article in Journal
Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(2), 2386-2396; https://doi.org/10.3390/molecules18022386

Synthesis and Crystal Structures of N-Substituted Pyrazolines

1
Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia
2
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, India
4
Department of Chemistry, P.A. College of Engineering, Nadupadavu, Mangalore-574 153, India
*
Author to whom correspondence should be addressed.
Received: 12 December 2012 / Revised: 2 February 2013 / Accepted: 7 February 2013 / Published: 20 February 2013
(This article belongs to the Section Organic Chemistry)
View Full-Text   |   Download PDF [821 KB, uploaded 18 June 2014]   |  

Abstract

Four pyrazole compounds, 3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde (1), 5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde (2), 1-[5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone (3) and 1-[3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one (4), have been prepared by condensing chalcones with hydrazine hydrate in the presence of aliphatic acids, namely formic acid, acetic acid and propionic acid. The structures were characterized by X-ray single crystal structure determination. The dihedral angles formed between the pyrazole and the fluoro-substituted rings are 4.64(7)° in 1, 5.3(4)° in 2 and 4.89(6)° in 3. In 4, the corresponding angles for molecules A and molecules B are 10.53(10)° and 9.78(10)°, respectively. View Full-Text
Keywords: synthesis; X-ray diffraction; pyrazole; crystal structure synthesis; X-ray diffraction; pyrazole; crystal structure
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Loh, W.-S.; Quah, C.K.; Chia, T.S.; Fun, H.-K.; Sapnakumari, M.; Narayana, B.; Sarojini, B.K. Synthesis and Crystal Structures of N-Substituted Pyrazolines. Molecules 2013, 18, 2386-2396.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top