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Molecules 2013, 18(2), 2376-2385; doi:10.3390/molecules18022376
Article

Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)

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Received: 7 January 2013; in revised form: 1 February 2013 / Accepted: 1 February 2013 / Published: 19 February 2013
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Abstract: As part of our ongoing research on antioxidant agents from Brazilian flora, we screened the free radical scavenging activity of two extracts and eight fractions of Kielmeyera variabilis (Clusiaceae) using DPPH· (2,2-diphenyl-1-picrylhydrazyl-hydrate) and ABTS·+ [2,2'-azinobis(3-ethylenebenzothiazoline-6-sulfonic acid)] colorimetric assays. The ethyl acetate and n-butanol fractions of the leaves of K. variabilis displayed the strongest activity (IC50 of 3.5 ± 0.3 and 4.4 ± 0.2 μg mL−1 for DPPH· and 6.6 ± 0.4 and 3.1 ± 0.1 μg mL−1 for ABTS·+, respectively). Chromatographic fractionation of the most potent fractions led to identification of three flavonols with previously described antioxidant activity, quercitrin (1), quercetin-3-O-b-glucoside (3), and quercetin-3-O-b-galactoside (4), and of one biflavone, podocarpusflavone A (2). This is the first time that the presence of these flavonoids in Kielmeyera variabilis has been reported.
Keywords: Kielmeyera variabilis; Clusiaceae; antioxidant; free radical scavenging activity; DPPH·; ABTS·+; flavonoid; flavonol Kielmeyera variabilis; Clusiaceae; antioxidant; free radical scavenging activity; DPPH·; ABTS·+; flavonoid; flavonol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Coqueiro, A.; Regasini, L.O.; Skrzek, S.C.G.; Queiroz, M.M.F.; Silva, D.H.S.; da Silva Bolzani, V. Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae). Molecules 2013, 18, 2376-2385.

AMA Style

Coqueiro A, Regasini LO, Skrzek SCG, Queiroz MMF, Silva DHS, da Silva Bolzani V. Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae). Molecules. 2013; 18(2):2376-2385.

Chicago/Turabian Style

Coqueiro, Aline; Regasini, Luis O.; Skrzek, Scheila C.G.; Queiroz, Marcos M.F.; Silva, Dulce H.S.; da Silva Bolzani, Vanderlan. 2013. "Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)." Molecules 18, no. 2: 2376-2385.



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