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Molecules 2013, 18(2), 2297-2306; doi:10.3390/molecules18022297
Article

Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta

1,* , 2, 1, 1, 2, 3, 3,4,*  and 5,*
Received: 13 December 2012 / Revised: 30 January 2013 / Accepted: 31 January 2013 / Published: 19 February 2013
(This article belongs to the Section Metabolites)
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Abstract

Phytochemical investigation of an ethanolic extract of stems of Schisandra neglecta led to the isolation and identification of two new dibenzocyclooctadiene lignans, designated neglschisandrins E (1) and F (2), and thirteen known lignans. All structures and stereochemistries were determined by spectroscopic methods, including 2D-NMR techniques. The isolates were evaluated for in vitro cytotoxic activity. Among them, compounds 26 exhibited moderate to weak cytotoxicity against the human colorectal carcinoma HCT-8 cell line with EC50 values of 7.33~19.8 μg/mL. In addition, compounds 24 also exhibited marginal cytotoxicity against the human lung carcinoma A549 cell line with EC50 values of 11.8~15.0 μg/mL.
Keywords: Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, M.; Xu, X.; Xu, B.; Yang, P.; Liao, Z.; Morris-Natschke, S.L.; Lee, K.-H.; Chen, D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules 2013, 18, 2297-2306.

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