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Molecules 2013, 18(2), 2297-2306; doi:10.3390/molecules18022297
Article

Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta

1,* , 2, 1, 1, 2, 3, 3,4,*  and 5,*
1 Key Laboratory on Luminescence and Real-Time Analysis (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China 2 School of Life Sciences, Southwest University, Chongqing 400715, China 3 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA 4 Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan 5 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China
* Authors to whom correspondence should be addressed.
Received: 13 December 2012 / Revised: 30 January 2013 / Accepted: 31 January 2013 / Published: 19 February 2013
(This article belongs to the Section Natural Products)
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Abstract

Phytochemical investigation of an ethanolic extract of stems of Schisandra neglecta led to the isolation and identification of two new dibenzocyclooctadiene lignans, designated neglschisandrins E (1) and F (2), and thirteen known lignans. All structures and stereochemistries were determined by spectroscopic methods, including 2D-NMR techniques. The isolates were evaluated for in vitro cytotoxic activity. Among them, compounds 26 exhibited moderate to weak cytotoxicity against the human colorectal carcinoma HCT-8 cell line with EC50 values of 7.33~19.8 μg/mL. In addition, compounds 24 also exhibited marginal cytotoxicity against the human lung carcinoma A549 cell line with EC50 values of 11.8~15.0 μg/mL.
Keywords: Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, M.; Xu, X.; Xu, B.; Yang, P.; Liao, Z.; Morris-Natschke, S.L.; Lee, K.-H.; Chen, D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules 2013, 18, 2297-2306.

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