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Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta
Key Laboratory on Luminescence and Real-Time Analysis (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
School of Life Sciences, Southwest University, Chongqing 400715, China
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China
* Authors to whom correspondence should be addressed.
Received: 13 December 2012; in revised form: 30 January 2013 / Accepted: 31 January 2013 / Published: 19 February 2013
Abstract: Phytochemical investigation of an ethanolic extract of stems of Schisandra neglecta led to the isolation and identification of two new dibenzocyclooctadiene lignans, designated neglschisandrins E (1) and F (2), and thirteen known lignans. All structures and stereochemistries were determined by spectroscopic methods, including 2D-NMR techniques. The isolates were evaluated for in vitro cytotoxic activity. Among them, compounds 2–6 exhibited moderate to weak cytotoxicity against the human colorectal carcinoma HCT-8 cell line with EC50 values of 7.33~19.8 μg/mL. In addition, compounds 2–4 also exhibited marginal cytotoxicity against the human lung carcinoma A549 cell line with EC50 values of 11.8~15.0 μg/mL.
Keywords: Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity
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Chen, M.; Xu, X.; Xu, B.; Yang, P.; Liao, Z.; Morris-Natschke, S.L.; Lee, K.-H.; Chen, D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules 2013, 18, 2297-2306.
Chen M, Xu X, Xu B, Yang P, Liao Z, Morris-Natschke SL, Lee K-H, Chen D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules. 2013; 18(2):2297-2306.
Chen, Min; Xu, Xiumei; Xu, Bing; Yang, Panpan; Liao, Zhihua; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Chen, Daofeng. 2013. "Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta." Molecules 18, no. 2: 2297-2306.