Abstract: Phytochemical investigation of an ethanolic extract of stems of Schisandra neglecta led to the isolation and identification of two new dibenzocyclooctadiene lignans, designated neglschisandrins E (1) and F (2), and thirteen known lignans. All structures and stereochemistries were determined by spectroscopic methods, including 2D-NMR techniques. The isolates were evaluated for in vitro cytotoxic activity. Among them, compounds 2–6 exhibited moderate to weak cytotoxicity against the human colorectal carcinoma HCT-8 cell line with EC50 values of 7.33~19.8 μg/mL. In addition, compounds 2–4 also exhibited marginal cytotoxicity against the human lung carcinoma A549 cell line with EC50 values of 11.8~15.0 μg/mL.
Keywords: Schisandra neglecta; Schisandraceae; dibenzocyclooctadiene lignan; neglschisandrins E–F; cytotoxicity
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Chen, M.; Xu, X.; Xu, B.; Yang, P.; Liao, Z.; Morris-Natschke, S.L.; Lee, K.-H.; Chen, D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules 2013, 18, 2297-2306.
Chen M, Xu X, Xu B, Yang P, Liao Z, Morris-Natschke SL, Lee K-H, Chen D. Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules. 2013; 18(2):2297-2306.
Chen, Min; Xu, Xiumei; Xu, Bing; Yang, Panpan; Liao, Zhihua; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Chen, Daofeng. 2013. "Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta." Molecules 18, no. 2: 2297-2306.