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Molecules 2013, 18(2), 2212-2221; doi:10.3390/molecules18022212
Article

An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles

1,*  and 2
Received: 14 December 2012; in revised form: 28 January 2013 / Accepted: 30 January 2013 / Published: 11 February 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: An efficient reduction of double bonds conjugated with nitrile groups and acid or base sensitive furan rings with 2-phenylbenzimidazoline generated in situ has been successfully accomplished with high yields and excellent selectivity. The employed reducing agent was prepared in one step from ordinary chemicals. The other advantages of the presented method include mild and convenient reaction conditions, a benign and cost effective reagent, simple work-up and separation of the products. As this process does neither affect cyano and nitro groups nor furan rings, it is a valuable alternative when metal-catalyzed hydrogenations or borohydride reductions have failed.
Keywords: chemoselective reduction; regioselective reduction; conjugated olefins; organic hydride compounds; furan ethylenes; unsaturated dinitriles; 2-phenylbenzimidazoline chemoselective reduction; regioselective reduction; conjugated olefins; organic hydride compounds; furan ethylenes; unsaturated dinitriles; 2-phenylbenzimidazoline
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bobal, P.; Bobalova, J. An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles. Molecules 2013, 18, 2212-2221.

AMA Style

Bobal P, Bobalova J. An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles. Molecules. 2013; 18(2):2212-2221.

Chicago/Turabian Style

Bobal, Pavel; Bobalova, Janette. 2013. "An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles." Molecules 18, no. 2: 2212-2221.


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