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Molecules 2013, 18(2), 2052-2060; doi:10.3390/molecules18022052

Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model

1,* , 1
1 Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan 2 Division of Basic Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan 3 Department of Mathematics, Tamkang University, Danshui Dist., New Taipei City 25137, Taiwan 4 Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan
* Authors to whom correspondence should be addressed.
Received: 18 December 2012 / Revised: 29 January 2013 / Accepted: 29 January 2013 / Published: 5 February 2013
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The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
Keywords: anti-inflammation; chalcone; fin; zebrafish anti-inflammation; chalcone; fin; zebrafish
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-H.; Wang, W.-H.; Wang, Y.-H.; Lin, Z.-Y.; Wen, C.-C.; Chern, C.-Y. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules 2013, 18, 2052-2060.

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