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Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model
Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan
Division of Basic Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan
Department of Mathematics, Tamkang University, Danshui Dist., New Taipei City 25137, Taiwan
Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan
* Authors to whom correspondence should be addressed.
Received: 18 December 2012; in revised form: 29 January 2013 / Accepted: 29 January 2013 / Published: 5 February 2013
Abstract: The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
Keywords: anti-inflammation; chalcone; fin; zebrafish
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Chen, Y.-H.; Wang, W.-H.; Wang, Y.-H.; Lin, Z.-Y.; Wen, C.-C.; Chern, C.-Y. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules 2013, 18, 2052-2060.
Chen Y-H, Wang W-H, Wang Y-H, Lin Z-Y, Wen C-C, Chern C-Y. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules. 2013; 18(2):2052-2060.
Chen, Yau-Hung; Wang, Wei-Hua; Wang, Yun-Hsin; Lin, Zi-Yu; Wen, Chi-Chung; Chern, Ching-Yuh. 2013. "Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model." Molecules 18, no. 2: 2052-2060.