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Molecules 2013, 18(2), 1985-1994; doi:10.3390/molecules18021985
Article

Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines

1, 1,* , 1, 2 and 3
Received: 17 December 2012; in revised form: 16 January 2013 / Accepted: 22 January 2013 / Published: 4 February 2013
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Abstract: The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
Keywords: cytotoxicity; Mesua beccariana; Mesua ferrea; Mesua congestiflora; structure-activity relationship; xanthones cytotoxicity; Mesua beccariana; Mesua ferrea; Mesua congestiflora; structure-activity relationship; xanthones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Teh, S.S.; Ee, G.C.L.; Mah, S.H.; Lim, Y.M.; Ahmad, Z. Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines. Molecules 2013, 18, 1985-1994.

AMA Style

Teh SS, Ee GCL, Mah SH, Lim YM, Ahmad Z. Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines. Molecules. 2013; 18(2):1985-1994.

Chicago/Turabian Style

Teh, Soek S.; Ee, Gwendoline C.L.; Mah, Siau H.; Lim, Yang M.; Ahmad, Zuraini. 2013. "Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines." Molecules 18, no. 2: 1985-1994.



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