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Molecules 2013, 18(2), 1973-1984; doi:10.3390/molecules18021973
Article

Synthesis and Characterization of Novel Unsymmetrical and Symmetrical 3-Halo- or 3-Methoxy-substituted 2-Dibenzoylamino-1,4-naphthoquinone Derivatives

1, 1, 1, 1, 1, 1, 1, 2 and 1,*
1 Department of Chemistry, Howard University, Washington, DC 20059, USA 2 Department of Natural Sciences, Bowie State University, Bowie, MD 20715, USA
* Author to whom correspondence should be addressed.
Received: 31 December 2012 / Revised: 30 January 2013 / Accepted: 30 January 2013 / Published: 4 February 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4-naphthoquinone, 2-amino-3-bromo-1,4-naphthoquinone and 2-amino-3-methoxy-1,4-naphthoquinone.
Keywords: 1,4-naphthoquinone; imide synthesis; sodium hydride-promoted bis-acylation; unsymmetrical imide 1,4-naphthoquinone; imide synthesis; sodium hydride-promoted bis-acylation; unsymmetrical imide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brandy, Y.; Brandy, N.; Akinboye, E.; Lewis, M.; Mouamba, C.; Mack, S.; Butcher, R.J.; Anderson, A.J.; Bakare, O. Synthesis and Characterization of Novel Unsymmetrical and Symmetrical 3-Halo- or 3-Methoxy-substituted 2-Dibenzoylamino-1,4-naphthoquinone Derivatives. Molecules 2013, 18, 1973-1984.

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