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Molecules 2013, 18(2), 1540-1548; doi:10.3390/molecules18021540
Communication

Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

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Received: 12 November 2012; in revised form: 16 January 2013 / Accepted: 22 January 2013 / Published: 25 January 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino)ethylene (TDAE) as reductant.
Keywords: TDAE; propargylic alcohol; organic reducing agent; aromatic aldehyde TDAE; propargylic alcohol; organic reducing agent; aromatic aldehyde
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Roche, M.; Terme, T.; Vanelle, P. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules 2013, 18, 1540-1548.

AMA Style

Roche M, Terme T, Vanelle P. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules. 2013; 18(2):1540-1548.

Chicago/Turabian Style

Roche, Manon; Terme, Thierry; Vanelle, Patrice. 2013. "Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives." Molecules 18, no. 2: 1540-1548.


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