Molecules 2013, 18(2), 1540-1548; doi:10.3390/molecules18021540
Communication

Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Manon Roche, Thierry Terme and Patrice Vanelle* email
Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 12 November 2012; in revised form: 16 January 2013 / Accepted: 22 January 2013 / Published: 25 January 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino)ethylene (TDAE) as reductant.
Keywords: TDAE; propargylic alcohol; organic reducing agent; aromatic aldehyde

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MDPI and ACS Style

Roche, M.; Terme, T.; Vanelle, P. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules 2013, 18, 1540-1548.

AMA Style

Roche M, Terme T, Vanelle P. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules. 2013; 18(2):1540-1548.

Chicago/Turabian Style

Roche, Manon; Terme, Thierry; Vanelle, Patrice. 2013. "Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives." Molecules 18, no. 2: 1540-1548.

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