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Molecules 2013, 18(12), 15126-15133; doi:10.3390/molecules181215126
Article

Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

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Received: 12 November 2013 / Revised: 29 November 2013 / Accepted: 4 December 2013 / Published: 6 December 2013
(This article belongs to the Section Metabolites)
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Abstract

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.
Keywords: halotolerant fungus; Myrothecium sp.; polyketide; furanone halotolerant fungus; Myrothecium sp.; polyketide; furanone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, T.; Zhu, J.; Zhang, S.-Y.; Li, Z.-L.; Guan, L.-P.; Pan, H.-Q.; Wu, X.; Bai, J.; Hua, H.-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules 2013, 18, 15126-15133.

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