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Molecules 2013, 18(12), 15126-15133; doi:10.3390/molecules181215126

Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

1,* , 2
1 Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China 2 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China 3 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 4 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China 5 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 29 November 2013 / Accepted: 4 December 2013 / Published: 6 December 2013
(This article belongs to the Section Metabolites)
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Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.
Keywords: halotolerant fungus; Myrothecium sp.; polyketide; furanone halotolerant fungus; Myrothecium sp.; polyketide; furanone
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Liu, T.; Zhu, J.; Zhang, S.-Y.; Li, Z.-L.; Guan, L.-P.; Pan, H.-Q.; Wu, X.; Bai, J.; Hua, H.-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules 2013, 18, 15126-15133.

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