Molecules 2013, 18(12), 15126-15133; doi:10.3390/molecules181215126

Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

1 Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China 2 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China 3 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 4 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China 5 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 12 November 2013; in revised form: 29 November 2013 / Accepted: 4 December 2013 / Published: 6 December 2013
(This article belongs to the Section Natural Products)
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Abstract: Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.
Keywords: halotolerant fungus; Myrothecium sp.; polyketide; furanone

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MDPI and ACS Style

Liu, T.; Zhu, J.; Zhang, S.-Y.; Li, Z.-L.; Guan, L.-P.; Pan, H.-Q.; Wu, X.; Bai, J.; Hua, H.-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules 2013, 18, 15126-15133.

AMA Style

Liu T, Zhu J, Zhang S-Y, Li Z-L, Guan L-P, Pan H-Q, Wu X, Bai J, Hua H-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules. 2013; 18(12):15126-15133.

Chicago/Turabian Style

Liu, Tao; Zhu, Jing; Zhang, Song-Ya; Li, Zhan-Lin; Guan, Li-Ping; Pan, Hua-Qi; Wu, Xin; Bai, Jiao; Hua, Hui-Ming. 2013. "Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17." Molecules 18, no. 12: 15126-15133.

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