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Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17
Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 12 November 2013; in revised form: 29 November 2013 / Accepted: 4 December 2013 / Published: 6 December 2013
Abstract: Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.
Keywords: halotolerant fungus; Myrothecium sp.; polyketide; furanone
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Liu, T.; Zhu, J.; Zhang, S.-Y.; Li, Z.-L.; Guan, L.-P.; Pan, H.-Q.; Wu, X.; Bai, J.; Hua, H.-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules 2013, 18, 15126-15133.
Liu T, Zhu J, Zhang S-Y, Li Z-L, Guan L-P, Pan H-Q, Wu X, Bai J, Hua H-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules. 2013; 18(12):15126-15133.
Liu, Tao; Zhu, Jing; Zhang, Song-Ya; Li, Zhan-Lin; Guan, Li-Ping; Pan, Hua-Qi; Wu, Xin; Bai, Jiao; Hua, Hui-Ming. 2013. "Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17." Molecules 18, no. 12: 15126-15133.