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Characterization of Flavonoids in the Ethomedicine Fordiae Cauliflorae Radix and Its Adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Guangxi Botanical Garden of Medicinal Plant, Nanning, Guangxi 530023, China
School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Guangxi Institute of Botany, the Chinese Academy of Science, Guilin, Guangxi 541006, China
School of Pharmacy, Guangxi University of Chinese Medicine, Guangxi 530001, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 14 October 2013; in revised form: 26 November 2013 / Accepted: 4 December 2013 / Published: 9 December 2013
Abstract: Fordiae Cauliflorae Radix (FC, the root of Fordia cauliflora Hemsl) and Millettiae Pulchrae Radix [MP, the root of Millettia pulchra (Benth.) Kurz var. laxior (Dunn) Z. Wei], which go under the same local name of “Daluosan”, have long been used in Southern China for the treatment of stroke, paralysis, dementia in children, Alzheimer’s disease and other diseases. The same local name and similar functions always confuse users. To further utilize these two ethnodrugs and identify them unambiguously, an HPLC-DAD-ESI-IT-TOF-MSn method was developed to separate and characterize the flavonoids in FC and MP. A total of 41 flavonoids were detected, of which six compounds were identified by comparing their retention time and MS data with those of the reference standards, and the others were tentatively identified based on their tandem mass spectrometry data obtained in the positive ion detection mode. Nineteen of these characterized compounds are reported from these two plants for the first time.
Keywords: Fordia cauliflora; Millettia pulchra var. laxior; HPLC-DAD-ESI-IT-TOF-MSn; flavonoids; identification; ethnomedicine
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MDPI and ACS Style
Fan, L.-L.; Yi, T.; Xu, F.; Zhang, Y.-Z.; Zhang, J.-Y.; Li, D.-P.; Xie, Y.-J.; Qin, S.-D.; Chen, H.-B. Characterization of Flavonoids in the Ethomedicine Fordiae Cauliflorae Radix and Its Adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn. Molecules 2013, 18, 15134-15152.
Fan L-L, Yi T, Xu F, Zhang Y-Z, Zhang J-Y, Li D-P, Xie Y-J, Qin S-D, Chen H-B. Characterization of Flavonoids in the Ethomedicine Fordiae Cauliflorae Radix and Its Adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn. Molecules. 2013; 18(12):15134-15152.
Fan, Lan-Lan; Yi, Tao; Xu, Feng; Zhang, Ya-Zhou; Zhang, Jian-Ye; Li, Dian-Peng; Xie, Yang-Jiao; Qin, Shan-Ding; Chen, Hu-Biao. 2013. "Characterization of Flavonoids in the Ethomedicine Fordiae Cauliflorae Radix and Its Adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn." Molecules 18, no. 12: 15134-15152.